Avoid concurrent administration w/ pimozide, terfenadine, astemizole or cisapride. May lower plasma conc of concomitantly administered S(-) warfarin, tolbutamide or phenytoin, drugs metabolized by CYP2C9. The usual dose of dexamethasone & methylprednisolone should be reduced. Caution & close monitoring when co-administered w/ chemotherapeutic agents metabolized primarily or in part by CYP3A4 (eg, etoposide, vinorelbine, docetaxel, ifosfamide, cyclophosphamide, irinotecan, paclitaxel). May increase plasma conc of concomitantly administered midazolam or other benzodiazepines metabolized via CYP3A4 (eg, alprazolam, triazolam). Concomitant administration w/ strong CYP3A4 inhibitors (eg, ketoconazole) or CYP3A4 inducers (eg, rifampin). OCs. Diltiazem, paroxetine.
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