Adult Acute treatment of schizophrenia & bipolar mania 40 mg bd, may be adjusted up to max 80 mg bd. Maintenance treatment of schizophrenia Administer at the lowest effective dose. In many cases, 20 mg bd may be sufficient.
Mild to moderate dose-related prolongation of the QT-interval. Neuroleptic malignant syndrome. Tardive dyskinesia & other tardive extrapyramidal syndrome after long-term treatment. Venous thromboembolism. Increased risk of CVA in the dementia population. Increased mortality in elderly people w/ dementia. Not for treatment of dementia-related behavioural disturbances. Patients w/ history of seizures; significant bradycardia; risk factors for stroke. Drug reaction w/ eosinophilia & systemic symptoms (DRESS). Rare hereditary problems of galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. Moderate influence on the ability to drive & use machines. Patients w/ hepatic insufficiency. Pregnancy & lactation. Neonates exposed to antipsychotics during 3rd trimester of pregnancy are at risk for extrapyramidal &/or w/drawal symptoms following delivery. Elderly.
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