Adult Emetogenic chemotherapy & RT 8 mg PO, 1-2 hr prior to chemotherapy or radiation, followed by 8 mg PO every 12 hr for a max of 5 days. Alternatively, 8 mg as slow IV or IM inj immediately before treatment, followed by 8 mg orally 12 hrly. To protect against delayed or prolonged emesis after the 1st 24 hr, continue orally up to 5 days after a course of treatment.
Highly emetogenic chemotherapy A single oral dose of up to 24 mg taken together w/ 12 mg oral dexamethasone Na phosphate, 1-2 hr before chemotherapy, may be used. Alternatively, a single dose of 8 mg by slow IV or IM inj immediately before chemotherapy, which may be followed by 2 further IV/IM doses of 8 mg 4 hr apart or by a constant infusion of 1 mg/hr for up to 24 hr. Alternatively, a max initial IV dose of 16 mg diluted in 50-100 mL of saline or other compatible infusion fluid & infused over not less than 15 min immediately before chemotherapy. Initial dose may be followed by 2 additional 8 mg IV/IM doses 4 hr apart. The efficacy of Zofran in highly emetogenic chemotherapy may be enhanced by the addition of a single IV dose of dexamethasone Na phosphate 20 mg administered prior to chemotherapy. To protect against delayed emesis after the 1st 24 hr, continue orally up to 5 days after a course of treatment.
Childn Single 5 mg/m
2 IV dose immediately before chemotherapy, followed by 4 mg PO 12 hr later. Continue w/ 4 mg bd PO for up to 5 days after a course of treatment.
Elderly >65 yr No alteration of oral dose or frequency of administration is required in patients >65 yr.
Elderly 65-74 yr The dose schedule for adults can be followed. All IV doses should be diluted in 50-100 mL of saline or other compatible infusion fluid & infused over 15 min,
≥75 yr Initial IV dose should not exceed 8 mg. All IV doses should be diluted in 50-100 mL of saline or other compatible infusion fluid & infuse over 15 min. The initial dose of 8 mg may be followed by 2 further IV doses of 8 mg, infused over 15 min & given no less than 4 hr apart.
Post-op nausea & vomiting Adult Prevention: 16 mg PO 1 hr prior to anaesth or single dose of 4 mg IM or slow IV at induction of anaesth. Treatment: Single dose of 4 mg IM or slow IV inj.
Childn aged ≥1 mth & adolescent Prevention: 0.1 mg/kg up to a max of 4 mg by slow IV inj either prior to, at or after induction of anaesth. Treatment: 0.1 mg/kg up to a max of 4 mg by slow IV inj. No data on the use of Zofran in the treatment of PONV in childn <2 yr.
Patient w/ moderate or severe hepatic impairment Max: 8 mg daily.
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