Monotherapy & combination w/ other oral antidiabetic agents Initially 500 mg ER tab once daily. May be increased in increments of 500 mg every 10-15 days on the basis of blood glucose measurements. Max: 2 g once daily.
Patient treated w/ metformin tab Starting dose of ER tab should be equiv to the daily dose of metformin IR tab.
Combination w/ insulin Initially 500 mg ER tab once daily.
Patient already treated w/ metformin & insulin combination therapy Dose should be equiv to the daily dose of metformin tab up to max of 1.5 g or 2 g respectively while insulin dosage is adjusted on the basis of blood glucose measurements.