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Individualize and adjust dose according to patient’s blood pressure response and tolerance.
Mild to Moderate Hypertension: Initial Dose: 75-150 mcg oral twice daily, in the morning and at bedtime. Dose may be increased in increments of 150 mcg/day until optimum response is achieved. Maintenance Dose: Most common range is 200-600 mcg/day given in 2 divided doses. Maximum Dose: 2,400 mcg/day in 2-3 divided doses. Sedative effects may be minimized by giving bulk of the daily dose at bedtime.
Severe Hypertension: Initial Dose: Increase to 300 mcg 3 times daily (900 mcg/day total loading dose).
