Sichuan Huiyu


Oncolife Corp
Concise Prescribing Info
Locally advanced or metastatic breast cancer & non-small cell lung cancer (NSCLC) after failure of prior chemotherapy. Treatment of advanced gastric adenocarcinoma, adenocarcinoma of the gastroesophageal junction & locally advanced squamous cell carcinoma of the head & neck (SCCHN) in combination w/ cisplatin & fluorouracil. Treatment of androgen independent (hormone refractory) metastatic prostate cancer in combination w/ prednisone.
Dosage/Direction for Use
Given by IV infusion in glucose 5% or sodium chloride 0.9% at conc not >0.74 mg/mL over 1 hr. Premedication: Dexamethasone 16 mg daily for 3 days starting 1 day before taking Docetaxel. Locally advanced or metastatic breast cancer As single agent: 100 mg/m2; in combination w/ doxorubicin: 75 mg/m2; in combination w/ trastuzumab: 100 mg/m2 every 3 wk, w/ trastuzumab administered wkly; in combination w/ capecitabine: 75 mg/m2 every 3 wk combined w/ capecitabine at 1,250 mg/m2 bid (w/in 30 min after a meal) for 2 wk followed by a wk rest period. NSCLC 75 mg/m2 once every 3 wk, for both 1st-line combination therapy & monotherapy after failure of previous chemotherapy. Gastric adenocarcinoma 75 mg/m2 given before cisplatin & fluorouracil, repeated every 3 wk. Induction treatment of head & neck cancer 75 mg/m2 given before cisplatin & fluorouracil every 3 wk for 3 cycles, followed by chemoradiotherapy or for 4 cycles when followed by radiotherapy alone. Prostate cancer 75 mg/m2 once every 3 wk w/ prednisone or prednisolone 5 mg orally bid given continuously.
Hypersensitivity. Do not use in patients w/ baseline neutrophil count of <1,500 cells/mm3 & severe liver impairment.
Special Precautions
Before each treatment, test blood for enough blood cells & sufficient liver function. Patient may experience fever or infections in case of WBC disturbance. Patients in whom alcohol intake should be avoided or minimized. May impair ability to drive or use machinery. Pregnancy & lactation.
Adverse Reactions
Neutropenia, anemia and skin reactions; fluid retention, ascites, pleural & pericardial effusion & wt gain; excessive tear formation (epiphora); ischemic colitis; heart failure; palmar-plantar erythrodysesthesia syndrome.
Drug Interactions
Modified metabolism w/ cyclosporine, terfenadine, ketoconazole, erythromycin & troleandomycin.
ATC Classification
L01CD02 - docetaxel ; Belongs to the class of plant alkaloids and other natural products, taxanes. Used in the treatment of cancer.
Doxel conc soln for infusion 20 mg/mL
(+ 4-mL vial of diluent) 1 mL x 1's
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