Hypersensitivity reactions eg, anaphylaxis & angioedema. Patients at risk of developing GI complication eg, those using any other NSAID or ASA concomitantly or those w/ prior history of GI disease eg, ulceration & GI bleeding. Patients w/ significant risk factors for CV events (eg, HTN, hyperlipidemia, DM, smoking). Not a substitute for ASA for prophylaxis of CV thromboembolic diseases. Preexisting significantly impaired renal function, uncompensated heart failure, or cirrhosis; history of cardiac failure, left ventricular dysfunction, pre-existing oedema. Fluid retention, oedema & HTN. Monitor patients w/ symptoms &/or signs suggesting liver dysfunction, or in whom an abnormal LFT has occurred. Dismiss use if signs of hepatic insufficiency occur, or if persistently abnormal LFTs (3 x ULN) are detected. Discontinue therapy when any of the organ system functions deteriorate; at the first appearance of skin rash, mucosal lesions, or any other sign of hypersensitivity. Patients w/ dehydration. Serious skin reactions including exfoliative dermatitis, SJS, TEN. May mask fever & other signs of inflammation. Co-administration w/ warfarin or other oral anticoagulants. Refrain from driving or operating of machinery if experiencing dizziness, vertigo or somnolence. Not recommended in women attempting to conceive. Elderly.