Discontinue use if seizure develops & in patients entering manic phase. History of mania/hypomania. Increased anxiety symptoms at the start of treatment (paradoxical anxiety). Avoid in patients w/ unstable epilepsy. Controlled epilepsy; DM, cutaneous bleeding abnormalities, history of bleeding disorders; patients on electroconvulsive therapy. Monitor patients for suicide risk in 1st few wk of treatment. Concomitant use w/ medicines known to affect platelet function (eg, atypical anti-psychotics & phenothiazines, TCAs, aspirin & NSAIDs). Hepatic impairment. Elderly.