Not to be used in patients w/ type 1 diabetes. Assess patients for ketoacidosis immediately if nonspecific symptoms eg, nausea, vomiting, anorexia, abdominal pain, excessive thirst, difficulty breathing, confusion, unusual fatigue or sleepiness occur, regardless of blood glucose level. Discontinue, evaluate patient, & institute prompt treatment if ketoacidosis is suspected. Patients at higher risk of ketoacidosis while on treatment include patients on very low carbohydrate diet, w/ acute illness, pancreatic disorders suggesting insulin deficiency (eg, type 1 diabetes, history of pancreatitis or pancreatic surgery), insulin dose reduction (including insulin pump failure), alcohol abuse, severe dehydration, & w/ history of ketoacidosis. Consider monitoring for ketoacidosis & temporarily discontinuing treatment in clinical situations known to predispose to ketoacidosis (eg, prolonged fasting due to acute illness or surgery) & monitor ketones, even if treatment has been interrupted. Evaluate patients w/ pain or tenderness, erythema, swelling in genital or perineal area, fever, malaise for necrotizing fasciitis. Discontinue & institute prompt treatment if necrotizing fasciitis of perineum (Fournier's gangrene) is suspected. Patients for whom empagliflozin-induced drop in BP could pose risk eg, w/ known CV disease, on anti-hypertensive therapy w/ history of hypotension or patients ≥75 yr. Monitor vol status (eg, physical exam, BP measurements, lab tests including haematocrit) & electrolytes carefully in case of conditions that may lead to fluid loss (eg, GI illness). Consider temporary interruption of treatment until fluid loss is corrected; in patients w/ complicated UTI including pyelonephritis & urosepsis. Contains lactose; not to be taken by patients w/ rare hereditary conditions of galactose intolerance eg, galactosaemia. Not recommended to initiate treatment in patients on dialysis. Assess renal function prior to initiation & periodically during treatment ie, at least yrly. Avoid use during pregnancy. Discontinue lactation during treatment. Childn <18 yr. Elderly ≥75 yr.