Vitamin B-complex, folic acid.
Each tablet contains: Thiamine Mononitrate (Vitamin B1) 100 mg, Pyridoxine HCl (Vitamin B6) 50 mg, Cyanocobalamin (Vitamin B12) 1.2 mg, Folic Acid 2.5 mg
Meganerv F-A Tablet is a high potency combination of neurotropic vitamins B1, B6 and B12, fortified with folic acid. This unique formulation promotes adequate nourishment of the different body systems especially the central and peripheral nervous systems, as well as act in a concerted effort to assure the proper production of red blood cells. The components of Meganerv F-A catalyze various basic biochemical processes, and thus are essential for optimum health.
Pharmacology: Thiamine (Vitamin B1) functions as a coenzyme of carbohydrate metabolism. It is specifically involved in the decarboxylation of alpha-ketoacids such as pyruvate and alpha-ketoglutarade, and utilization of pentose in the hexose monophosphate shunt. Without thiamine, pyruvic acid cannot be further biotransformed into active acetate, which is utilized to produce the energy needed for cellular activities. Also, impaired oxidation of the alpha-ketoacids leads to the accumulation of metabolites of the reaction, which are toxic to the cells of the central nervous system (CNS). Thus, thiamine ensures the efficient metabolism of glucose and the conversion of glucose into ribose, a major component of DNA and RNA. Thiamine activates production of energy from glucose and storage of energy as fat, making energy available to support normal cellular processes.
Thiamine is especially needed for the normal functions of the gastrointestinal, cardiovascular and nervous systems of the body. The smooth muscle cells of the heart, blood vessels, and the secretory glands of the gastrointestinal tract depend on the energy derived from metabolism of glucose, which thiamine catalyzes. A lack of thiamine leads to weakness in these smooth muscles. The cells of the CNS also depend exclusively on glucose as its source of energy. When there is thiamine deficiency, glucose utilization by nervous tissue decreases markedly, and communication in many different portions of the CNS is disrupted. Independent of its coenzyme function, thiamine also acts as a modulator in the transmission of neural impulses.
Thiamine deficiency can cause degeneration of myelin sheaths in the peripheral nerves and in the CNS. This can lead to polyneuritis, a condition characterized by radiating pain along the course of one or more peripheral nerves.
Pyridoxine (Vitamin B6) participates in many cellular reactions of lipid and amino acid metabolism. The active form of B6, Pyridoxal phosphate, acts as a coenzyme in several metabolic transformations of amino acids, which are in turn needed for tissue building and repair, and the synthesis of blood elements and certain compounds like neurotransmitters.
Vitamin B6 is required in the synthesis of delta-aminolevulinic acid, the precursor of heme, which is necessary for the formation of the hemoglobin molecule. Thus, pyridoxine is essential for proper synthesis of red blood cells. Pyridoxine is also of particular importance in the synthesis of neurotransmitters, which are required for the normal activity of the brain and the entire CNS.
A deficiency of pyridoxine causes abnormal CNS function, with hyperirritability, neuritis, and even convulsions.
A large portion of the body's pyridoxine is found in phosphorylase (approximately half is found in skeletal phosphorylase), the enzyme that converts glycogen (stored carbohydrate) to glucose-1-phosphate, the carbohydrate form that can be used for energy.
Meganerv F-A contains high amounts of cyanocobalamin (Vitamin B12), a coenzyme involved in several metabolic pathways. Among the important actions of cyanocobalamin is to act as a coenzyme of nucleic acid metabolism, reducing ribonucleotides to deoxyribonucleotides, a step that is essential in the replication of genes and formation of new cells, and the conversion of methylmalonyl coA to succinyl coA. Cyanocobalamin is also an important cofactor in the formation and maturation of red blood cells in the bone marrow.
Deficiency of cyanocobalamin results in megaloblastic anemia.
Cyanocobalamin is also involved in the formation of myelin sheaths in nervous tissue. A deficiency causes demyelination of the large nerve fibers of the spinal cord. The inhibition of normal fatty acid synthesis in the brain and nerve tissues leads to faulty structure and impaired functions manifested as neurological symptoms.
Folic acid, in its reduced form tetrahydrofolate, participates in many reactions involving one-carbon transfers. It is involved in the conversion of homocysteine to methionine and in the conversion of deoxyuridylate to thymidylate, an essential step required in the synthesis of DNA.
Folic acid is necessary for the normal production of red blood cells, including maturation of megaloblasts into normoblast.
Painful neurological manifestations such as neuritis, polyneuritis, neuralgia, lumbago, ischialgia, sciatica, cervical and shoulder arm syndrome.
Neuropathies associated with certain disease states such as diabetes mellitus and cardiac disorders; alcoholic neuropathy; iatrogenic complications arising from INH, reserpine, and phenothiazine therapy; other drug induced neuropathies, neuropathic changes during pregnancy, hyperemesis gravidarum.
Prophylaxis and treatment of nutritional megaloblastic anemia associated with folic acid deficiency, as in hemolytic anemia, pernicious anemia, alcoholism, and that following gastrectomy.
Prevention of neural tube defects.
As adjunct in the treatment of colorectal carcinoma, ulcerative colitis, sickle cell diseases, and homocysteinemia.
To correct decreased folate levels when taking the following: Methotrexate, trimethoprim, sulfamethoxazole, phenytoin, and oral contraceptive pills.
For therapeutic use, 2-4 tablets should be administered daily. Chronic cases that may require longer therapy must be under constant physician supervision. For prophylactic use when diseases or drugs are likely to lead to neurological complications, 1-2 tablets daily is recommended.
For prophylaxis and treatment of anemia associated with folic acid deficiency, one tablet daily.
For the prevention of neural tube defects in women at high risk, 1-4 tablets daily, taken at least one month before conception through the first trimester of pregnancy.
Or as prescribed by the physician.
Folic acid should not be used in the therapy of patients with vitamin B12 deficiency of any cause unless there is associated folate deficiency. Proper hematological diagnosis is essential. The folic acid content of one tablet a day however, is unlikely to mask pernicious anemia should this condition be present. There are no known contraindications to the other components of Meganerv F-A, as used in this formulation.
The formulation consists of vitamins B1, B6, B9 and B12 which are all water-soluble. Any excess intake will be readily eliminated in the urine, and the formulation is therefore safe for long-term use. Folic acid is usually well tolerated in the dosage prescribed. Folic acid may partially reverse the anti-epileptic effects of phenobarbital, diphenylhydantoin, and primidone, and thereby increase seizure frequency. The combination of folic acid and vitamin B12 makes it safe to use in the treatment of pernicious anemia. Sensitivity to vitamin B1 may sometimes be encountered.
Sensitivity may occur if administration is at prolonged intervals, is irregular, or if the initial dose is low and is suddenly increased. Liver dysfunction also seems to predispose patients to hypersensitivity reactions. Nevertheless, it must be stressed that hypersensitivity to vitamin B1 is very rare when given orally and is encountered more often only when given by intravenous injection.
Store at temperatures not exceeding 30°C.
B03AE10 - various combinations ; Belongs to the class of iron in other combinations. Used in the treatment of anemia.
Meganerv F-A tab
100's (P1,900/pack)
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