Nasatapp Flu

Paracetamol, phenylephrine hydrochloride, chlorphenamine maleate.

Paracetamol/phenylephrine HCl/chlorphenamine maleate (Nasatapp Flu) is a peach to light-orange to orange tablet, round, beveled edge, bisected on one side and plain on one side.
Each tablet contains: Paracetamol, USP 500 mg, Phenylephrine HCl 25 mg, Chlorphenamine maleate 2 mg.

The medicine contains paracetamol, phenylephrine HCl, and chlorphenamine maleate. Paracetamol is an effective fever reducer and pain reliever. Phenylephrine HCl, a nasal decongestant, clears obstructed air passages and nasal sinuses due to congestion making breathing easier. It also reduces postnasal drip. Chlorphenamine maleate, an anti-allergy, relieves symptoms such as runny nose, sneezing, and itchy, watery eyes.

Used in the reduction of fever or relieves pain in common upper respiratory infection, runny nose, nasal congestion, allergic rhinitis and sinusitis.

Adult: 1 tablet every four hours.
Children (6-12 years old): ½ tablet every four hours or as prescribed by the physician.
Missed dose: If the patient missed a dose, just take the next dose if still needed for the condition being treated, and the subsequent doses at the recommended time or schedule (i.e., every 6 hours). Do not double dose.

Paracetamol: Overdose of paracetamol usually involves 4 phases with the following signs and symptoms: Eating disorder, nausea, vomiting, malaise, and excessive sweating.
Right upper abdominal pain or tenderness, liver enlargement which may be characterized by abdominal discomfort of "feeling full", elevated bilirubin and liver enzyme concentrations, prolongation of prothrombin time, and occasionally decreased urine output.
Eating disorder, nausea, vomiting, and malaise recur and signs of liver failure (e.g., jaundice) and possibly kidney failure and cardiomyopathy (disorder of the heart muscle) may develop.
Recovery or progression to fatal complete liver failure.
Phenylephrine HCl: Increased blood pressure; headache; seizures; palpitation; paresthesia (sensation of tingling, pricking or numbness of the skin); cerebral hemorrhage (bleeding from a ruptured blood vessel in the brain).
Chlorphenamine maleate: Extreme sleepiness or prolonged drowsiness; weakness; hallucination; convulsion; agitation; irritability; tachycardia; coma.
What to do when the patient has taken more than the recommended dosage: If the patient has taken more than the recommended dosage, consult a doctor or contact a poison control center right away, even if the patient seems well, because of the risk of delayed, serious liver damage. Quick medical attention is important for adults as well as for children even if the patient do not notice any signs or symptoms.

Do not take the medicine: If the patient is allergic to any ingredient of the product; If the patient has high blood pressure or severe heart disease unless recommended by a doctor; If the patient has anemia, kidney or liver disease unless recommended by a doctor; If the patient is pregnant or breastfeeding.

Care that should be taken when taking the medicine: Withdraw medication if drowsiness, restlessness or nervousness occurs.
Do not drive or operate machinery.
Heart, blood pressure, and diabetes patients should use with caution.
Do not use after the expiry date on the label.
Before taking the medication, tell the doctor if the patient has: High blood pressure; Glaucoma; Thyroid problems; Diabetes; Liver or kidney disease; An enlarged prostate, bladder problems or difficulty urinating.

Paracetamol: Paracetamol, when taken within the recommended dose and duration of treatment, has low incidence of side effects.
Blood and lymphatic system disorders: Changes in the number of white blood cells and platelets such as agranulocytosis (decrease in the number of granulocytes), leukopenia (decrease in the number of leukocytes), neutropenia (decrease in the number of neutrophils), pancytopenia (deficiency of all cellular elements in the blood), thrombocytopenia (decrease in the number of platelets).
Immune system disorders: Allergic reactions which may cause difficulty in breathing, skin rash, angioedema (swelling of the face or throat).
Gastrointestinal disorders: Minor stomach and intestinal disturbances.
Skin and subcutaneous tissue disorders: Rare cases of serious skin reactions (i.e., Stevens-Johnson syndrome, toxic epidermal necrolysis and acute generalized exanthematous pustulosis) which may include symptoms such as reddening of the skin, rash, blisters and detachment of the upper surface of the skin have been reported with paracetamol.
Phenylephrine HCl: Psychiatric disorders: Anxiety (feeling of uneasiness), insomnia/sleeplessness, nervousness.
Nervous system disorders: Dizziness, restlessness, tremor (muscle shaking).
Cardiac disorders: Arrhythmia (irregular heart beat), palpitation.
Vascular disorders: Increased blood pressure, pallor.
Respiratory, thoracic and mediastinal disorders: Respiratory distress (noisy, congested breathing).
General disorders and administration site conditions: Weakness.
Chlorphenamine maleate: Chlorphenamine maleate may cause sleepiness and drowsiness.
Psychiatric disorders: Insomnia/sleeplessness, nervousness.
Nervous system disorders: Headache, tremor (muscle shaking).
Eye disorders: Blurred vision, visual disturbance.
Ear and labyrinth disorders: Tinnitus (ringing in the ears).
Cardiac disorders: Chest tightness.
Vascular disorders: Increased or decreased blood pressure.
Gastrointestinal disorders: Constipation, diarrhea, gastrointestinal discomfort, nausea, vomiting.
Musculoskeletal and connective tissue disorders: Muscle weakness.
Renal and urinary disorders: Difficulty urinating.
General disorders and administration site conditions: Dryness of the mouth, nose, and throat; irritability.

Do not use the product together with sympathomimetic agents (e.g., epinephrine) and general anesthetics (e.g., halothane) because of the possibility for increased toxicity.
Concurrent administration with medicines for depression such as monoamine oxidase (MAO) inhibitors (e.g., selegiline, moclobemide) and tricyclic antidepressants (e.g., amitriptyline, imipramine) may result in hypertensive crisis (sudden, severe increase in blood pressure that can lead to stroke).
Taking an alpha-adrenergic blocking agent (e.g., phenothiazine drugs, phentolamine) before the administration of the product may decrease the effect of phenylephrine.
Concomitant use with beta-adrenergic blocking agents (e.g., propranolol) and methyldopa may cause an increase in blood pressure.
Medicines that cause sedation such as anxiolytics (e.g., alprazolam, diazepam) and hypnotics (e.g., zolpidem) may potentiate drowsiness.
Paracetamol, when used together with warfarin (a blood-thinning medicine), may cause an increase in the International Normalized Ratio (INR), which may serve as a sign of increased risk for bleeding. Paracetamol increases the anticoagulation effect of warfarin.
Medicines which stimulate the enzymes responsible for the metabolic activation of paracetamol such as medicines for convulsion (e.g., phenobarbital, phenytoin) may increase susceptibility to the harmful effects to the liver.
The absorption of paracetamol may be accelerated by metoclopramide or domperidone and reduced by cholestyramine.
Tell the doctor about other medicines the patient is taking (i.e., other medicines for cough, cold, allergy, pain, or fever, especially other paracetamol-containing products).

Store at temperatures not exceeding 30°C.

Cough & Cold Preparations

R01BA53 - phenylephrine, combinations ; Belongs to the class of systemic sympathomimetic preparations used as nasal decongestants.

Non-Rx