Oxitone

Oxytocin

Induction of labor, stimulation of labor in hypotonic uterine inertia; management of missed & incomplete abortion; postpartum hemorrhage in patients who do not respond to ergometrine.

IV drip infusion 1 u of oxytocin in 1 L 5% dextrose soln delivers approx 1 milliunit/min when infused at a rate of 1.5 drops/min. Induction or stimulation of labor Physiological oxytocin infusion: 2-5 milliunits/min. Pharmacological oxytocin infusion: Initially 1.53 milliunits/min adjusted gradually until contractions occur every 2-5 min; infusion rate: Max 12 milliunits/min. Oxytocin titration: Initially 1 milliunit/min, then double the rate of flow every 20 min, until contractions last 40-50 sec occurring at intervals of 2-3 min. Doses of oxytocin up to 128 milliunits/min have been used. Missed abortion 10-20 u/500 mL of 5% dextrose soln increasing by 10-20 u/500 mL every hr to a max of 100 u/500 mL if necessary. Infusion rate: 10-30 drops/min.

Hypertonic uterine inertia, mechanical obstruction to delivery, failed trial labor, severe toxemia, predisposition to amniotic fluid embolism, fetal distress & placenta previa.

Caution should be exercised in patients w/ parity & previous caesarian section. CV disorders.

Uterine spasm, very high dose may cause violent uterine contractions leading to uterine rupture, tissue damage & asphyxia of the fetus.

Prostaglandins may potentiate the effects of oxytocin.

Drugs Acting on the Uterus

H01BB02 - oxytocin ; Belongs to the class of oxytocin and analogues. Used in posterior pituitary lobe hormone preparations.

Rx