Polynerv Forte

Paracetamol, thiamine mononitrate (vit B₁), pyridoxine HCl (vit B₆), cyanocobalamin (vit B₁₂).

Each film coated tablet contains thiamine mononitrate (vit. B₁) 150 mg, pyridoxine HCl (vit. B₆) 100 mg, cyanocobalamin (vit. B₁₂) 3000 mcg, paracetamol 600 mg.
Polynerv Forte is a high potency formulation of the neurotropic vitamins B₁, B₆ and B₁₂, reinforced with an analgesic, paracetamol. This unique formulation promotes adequate nourishment of the different body systems especially the central and peripheral nervous systems, as well as alleviate painful conditions that accompany neuromuscular illnesses. The vitamin B components of Polynerv Forte catalyze various basic biochemical processes required in promoting nervous system physiology. Paracetamol, with its pain relieving actions, complements the nerve soothing actions of vitamins B₁, B₆ and B₁₂.

Vitamins B₁, B₆ and B₁₂ are important factors in maintaining normal nerve metabolism. Any metabolic disorder that can result from the deficiency in these factors and or concomitant nerve injury can therefore cause peripheral neuropathies that usually present as sensory, motor and or autonomic impairment.
Since numbness and painful paresthesias often accompany peripheral neuropathies. Paracetamol, a proven safe and dependable analgesic coupled with B-complex supplementation can be employed to provide support in the management of the disease processes affecting neuromuscular system and their symptoms.
Thiamine (vitamin B₁) functions as a coenzyme of carbohydrate metabolism. It is specifically involved in the decarboxylation of alpha-ketoacids such as pyruvate and alpha-ketoglutarate. Impaired oxidation of the alpha-ketoacids leads to the accumulation of metabolites of the reaction, which are toxic to the cells of the central nervous system (CNS). Thus, thiamine promotes efficient metabolism of glucose and the conversion of glucose into other substances such as ribose, a major component of DNA and RNA. Thiamine activates production of energy from glucose and storage of energy as fat, making energy available to support normal cellular processes.
Thiamine is essential for the normal functions of the gastrointestinal, cardiovascular and nervous systems of the body. The smooth muscle cells of the heart, blood vessels, and the secretory glands of the gastrointestinal tract depend on the energy derived from metabolism of glucose, which thiamine catalyzes. A lack of thiamine leads to weakness in these smooth muscles. The cells of the CNS also depend exclusively on glucose as its source of energy. When there is thiamine deficiency, glucose utilization by nervous tissues decreases markedly, and communication in many different portions of the CNS is disrupted. Independent of its coenzyme function, thiamine also acts as a modulator in the transmission of neural impulses. Thiamine deficiency can cause degeneration of myelin sheaths in the peripheral nerves and in the CNS. This can lead to polyneuritis, a condition characterized by radiating pain along the course of one or more peripheral nerves.
Pyridoxine (vitamin B₆) participates in many cellular reactions of lipid and amino acid metabolism. The active form of B₆, pyridoxal phosphate, acts as a coenzyme in several metabolic transformations of amino acids, which are in turn needed for tissue building and repair, and in the synthesis of blood elements and certain compounds like neurotransmitters. Vitamin B₆ is required in the synthesis of delta-aminolevulinic acid, the precursor of heme, which is necessary for the formation of the hemoglobin molecule. Thus pyridoxine is essential for proper synthesis of red blood cells. Pyridoxine is also of particular importance in the synthesis of neurotransmitters, which are required for the normal activity of the nervous system. A deficiency of pyridoxine causes abnormal CNS function, with hyperirritability, neuritis, and even convulsions.
Polynerv Forte contains high amounts of cyanocobalamin (vitamin B₁₂), a coenzyme involved in several metabolic pathways. Among the important actions of cyanocobalamin is to act as a coenzyme of nucleic acid metabolism, reducing ribonucleotides to deoxyribonucleotides, a step that is essential in the replication of genes and formation of new cells, and the conversion of methylmalonyl CoA to succinyl CoA. Cyanocobalamin is likewise an important co-factor in the formation and maturation of red blood cells in the bone marrow.
Cyanocobalamin is also involved in the formation of myelin sheaths in nervous tissues. A deficiency causes demyelination of the large nerve fibers of the spinal cord. The inhibition of normal fatty acid synthesis in the brain and nerve tissues leads to faulty structure and impaired functions manifested as neurological symptoms.
Paracetamol relieves pain by blocking the production of prostaglandin, the chemical that causes pain, through the inhibition of the enzyme cyclooxygenase.

Painful neurological manifestations such as neuritis, polyneuritis, neuralgia, lumbago, ischialgia, sciatica, cervical and shoulder-arm syndrome.
Neuropathies caused by certain disease states such as diabetes mellitus and cardiac disorders. Alcoholic neuropathy, acute and chronic painful paresthesias, neuralgias (ischialgia, trigeminal neuralgia, lumbalgia) and in cases such as peripheral nerve impingement (Carpal tunnel syndrome, cervical shoulder-arm syndrome, cervical spondylosis, herniated disc with root impingement), trauma (nerve transaction, crush injuries, traction injuries), or infection (herpes zoster or shingles).

For therapeutic use, 2-4 tablets should be administered daily. Chronic cases which may require longer therapy must be under the supervision of a physician.
Or as prescribed by the physician.

Liver failure, renal failure, history of hypersensitivity to paracetamol and other active components.

Cyanocobalamin (vitamin B₁₂) should not be used to treat megaloblastic anemia of pregnancy. Administration of doses greater than 10 mcg of vitamin B₁₂ daily may produce a haematological response in patients with folate deficiency; indiscriminate use may mask the precise diagnosis.

The formulation contains vitamins B₁, B₆ and B₁₂ which are all water soluble. Any excess intake will be readily eliminated in the urine. Sensitivity to vitamin B₁ may sometimes be encountered. Sensitivity may occur if administration is at prolonged intervals, is irregular, or if the initial dose is low and is suddenly increased. Liver dysfunction also seems to predispose patients to hypersensitivity reactions. Nevertheless, it must be stressed that hypersensitivity to vitamin B₁ is very rare when given orally and is encountered more often only when given by intravenous injection.
Paracetamol is generally safe and well tolerated. Rashes and other transient and mild allergic reactions may be occasionally encountered.

Store at temperatures not exceeding 30°C.

Analgesics (Non-Opioid) & Antipyretics

N02BE51 - paracetamol, combinations excl. psycholeptics ; Belongs to the class of anilide preparations. Used to relieve pain and fever.

Rx