Rabeloc 20: Active duodenal & gastric ulcer. H.pylori +ve duodenal ulcers in combination w/ appropriate antibiotics eg, amoxicillin & clarithromycin as part of eradication programme. Symptomatic erosive or ulcerative GERD or non-erosive reflux disease (NERD). Maintenance treatment of healed erosive or ulcerative GERD. Sequential therapy (step-down) from IV rabeprazole Na. Rabeloc IV: Active duodenal or gastric ulcer w/ bleeding or severe erosions. Severe erosive or ulcerative GERD or NERD where patient is unable to take oral PPIs. Stress-induced mucosal injury in critical care. Prevention of acid-aspiration during surgery. Sequential therapy (step-up) from oral rabeprazole.
Active duodenal & benign gastric ulcer 20 mg once daily in the morning. Erosive or ulcerative GERD 20 mg once daily for 4-8 wk. GERD long-term management 10 or 20 mg once daily up to 12 mth. Zollinger Ellison syndrome 60 mg daily. Range: 20-120 mg daily. IV Alternative to continued oral therapy Recommended adult dose: 20 mg once daily by IV bolus over 15 min or by IV infusion for 7-10 days.
Potential interaction w/ compd that have pH dependent absorption; cyclosporin. Decreased ketoconazole levels by 33% & increased digoxin trough levels by 22% in normal subjects.
A02BC04 - rabeprazole ; Belongs to the class of proton pump inhibitors. Used in the treatment of peptic ulcer and gastro-oesophageal reflux disease (GERD).
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