RiteMed Glibenclamide Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Glibenclamide

Indications/Uses

Type 2 DM.

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Dosage/Direction for Use

Initially 2.5-5 mg daily. May adjust dose at intervals w/ 2.5 mg increments. Max: 20 mg daily. Doses >10 mg daily may be given in divided doses.

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Overdosage

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Administration

Should be taken with food: Take immediately before breakfast.

Contraindications

Insulin dependent DM or Type I DM. NIDDM. Porphyria; ketoacidosis, stress, severe infection, trauma or other severe conditions. Hepatic & renal insufficiency/failure. Pregnancy & lactation.

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Special Precautions

Patients w/ CV disease; debilitated, malnourished & adrenal or pituitary insufficiency. May impair ability to drive or operate machinery. Renal & hepatic impairment. Fasting patients. Elderly.

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Use In Pregnancy & Lactation

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Adverse Reactions

Headache, sleepiness, dizziness, nausea, vomiting, heartburn, diarrhea, constipation, abdominal pain, pruritus, rashes & photosensitivity; cholestatic jaundice, eosinophilia, transient leukopenia, thrombocytopenia, aplastic anemia, agranulocytosis, haemolytic anemia, erythema multiforme, & exfoliative dermatitis; hypoglycemic coma; increased appetite, wt gain, enhance water clearance.

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Drug Interactions

Reduced effect w/ epinephrine, chlorpromazine, corticosteroids, OCs, thiazides & thyroid hormone. Reduced hypoglycemic effect w/ rifampicin. Hypoglycemic effect may be heightened by ACE inhibitors, alcohol, allopurinol, selected analgesics eg, phenylbutazone & salicylates, ketoconazole, fluconazole & miconazole, chloramphenicol, cimetidine, clofibrate, coumarins, fluoroquinolones, heparin, MAOIs, ranitidine, sulphonamides, tetracyclines & TCAs. May increase effect & mask typical sympathetic warning signs w/ β-blockers.

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Storage

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Description

View RiteMed Glibenclamide description for details of the chemical structure and excipients (inactive components).

Action

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MIMS Class

Antidiabetic Agents

ATC Classification

A10BB01 - glibenclamide ; Belongs to the class of sulfonylureas. Used in the treatment of diabetes.

Regulatory Classification

Presentation/Packing

Form

RiteMed Glibenclamide tab 5 mg

Packing/Price

100's (P5.8/tab, P580/box)

RiteMed Glibenclamide

glibenclamide

Manufacturer:

Interphil

Distributor:

RiteMED