RiteMED Gliclazide Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Caution For Usage Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Gliclazide

Indications/Uses

Non insulin-dependent diabetes (type 2) in adults when dietary measures, physical exercise & wt loss alone are not sufficient to control blood glucose.

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Dosage/Direction for Use

Starting dose: 30 mg daily. May be increased to 60 mg, 90 mg or 120 mg daily, in successive steps if blood glucose is not adequately controlled. Interval between each dose increment should be at least 1 mth except in patient whose blood glucose has not reduced after 2 wk of treatment. Max daily dose: 120 mg. Switching from tab containing 80 mg of gliclazide to gliclazide MR tab 1 tab containing 80 mg of gliclazide is comparable to 1 MR tab of gliclazide. Switching from another oral antidiabetic agent to gliclazide Starting dose: 30 mg. Switching from a hypoglycaemic sulphonylurea w/ a prolonged t_1/2 Treatment free period of few days may be necessary, initially 30 mg daily followed by stepwise increase depending on metabolic response. Patient at risk of hypoglycaemia Min daily starting dose: 30 mg.

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Overdosage

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Administration

Should be taken with food: Take as single intake at breakfast time. Swallow whole.

Contraindications

Hypersensitivity to gliclazide, other sulfonylureas & sulphonamides. Type 1 diabetes. Diabetic pre-coma & coma, ketoacidosis. Severe renal or hepatic insufficiency. Treatment w/ miconazole. Lactation.

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Special Precautions

Hypoglycaemia. Blood glucose control in patient receiving antidiabetic treatment may be affected by St. John's Wort prep, fever, trauma, infection or surgical intervention. Dysglycaemia. Patients w/ G6PD-deficiency. Measurement of glycated haemoglobin levels (or fasting venous plasma glucose) is recommended. May affect ability to drive & operate machinery. Renal & hepatic insufficiency. Pregnancy & lactation. Childn & adolescents. Elderly.

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Use In Pregnancy & Lactation

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Adverse Reactions

Hypoglycaemia. GI disturbances, including abdominal pain, nausea, vomiting, dyspepsia, diarrhoea, constipation. Transient visual disturbances.

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Drug Interactions

Increased hypoglycaemic effect w/ miconazole (systemic route, oromucosal gel) & phenylbutazone (systemic route). Avoid alcohol or medicines containing alcohol. Potentiation of blood glucose lowering effect w/ other anti-diabetic agents (insulins, acarbose, metformin, thiazolidinediones, dipeptidyl peptidase-4 inhibitors, GLP-1 receptor agonists), β-blockers, fluconazole, ACE inhibitors (captopril, enalapril), H₂-receptor antagonists, MAOIs, sulphonamides, clarithromycin & NSAIDs. May increase blood glucose levels w/ danazol. Reduced insulin release w/ high doses of chlorpromazine. Increased blood glucose levels w/ possible ketosis w/ glucocorticoids (systemic & local route: IA, cutaneous & rectal prep) & tetracosactrin. Increase blood glucose levels due to β₂ agonist effects w/ ritodrine, salbutamol, terbutaline (IV). Decreased exposure w/ St. John's wort prep. May cause dysglycaemia w/ fluoroquinolones. Potentiation of anticoagulation w/ warfarin.

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Caution For Usage

For caution against possible variation of physical aspect of medicine... Click to view RiteMED Gliclazide detailed prescribing information

Storage

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Description

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Action

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MIMS Class

Antidiabetic Agents

ATC Classification

A10BB09 - gliclazide ; Belongs to the class of sulfonylureas. Used in the treatment of diabetes.

Regulatory Classification

Presentation/Packing

Form

RiteMED Gliclazide tab 80 mg

Packing/Price

60's (P6.75/tab, P405/box)

RiteMED Gliclazide

gliclazide

Manufacturer:

RiteMED

Distributor:

United Lab