Use of nitrates during early days of acute phase of MI. Nitrate dependence may occur w/ chronic use. Gradually reduce administration to avoid possible w/drawal effects (eg, chest pain, acute MI & sudden death). Do not discontinue abruptly. May develop tolerance to isosorbide & cross-tolerance to other nitrates & nitrites. Patients w/ glaucoma. May cause a slight decrease in mean BP (approx 10-15 mmHg). Patients prone or might be affected by hypotension. Pregnancy.