Atozet Dosage & Drug Information

Concise Prescribing Info

Contents

FC tab 10/10 mg: Ezetimibe 10 mg, atorvastatin 10 mg. FC tab 10/20 mg: Ezetimibe 10 mg, atorvastatin 20 mg. FC tab 10/40 mg: Ezetimibe 10 mg, atorvastatin 40 mg. FC tab 10/80 mg: Ezetimibe 10 mg, atorvastatin 80 mg

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Indications/Uses

Adjunctive therapy to diet for use in adults w/ primary (heterozygous familial & non-familial) hypercholesterolaemia or mixed hyperlipidaemia where use of a combination product is appropriate. Reduction of elevated total-C & LDL-C levels in patients w/ HoFH.

Dosage/Direction for Use

Individualized dosage. Adult Primary hypercholesterolemia Initially 10/10 or 10/20 mg once daily. Dosage range: 10/10-10/80 mg once daily. Patient who require larger LDL-C reduction (>55%) Initially 10/40 mg once daily. Adjust dose accordingly & analyze lipid levels w/in ≥2 wk after initiation &/or upon titration. HoFH 10/40 or 10/80 mg daily, as an adjunct to other lipid-lowering treatments (eg, LDL apheresis). Co-administration w/ bile acid sequestrant Administer Atozet ≥2 hr before or ≥4 hr after. Patient taking clarithromycin, itraconazole, boceprevir, elbasvir, grazoprevir, saquinavir + ritonavir, darunavir + ritonavir, fosamprenavir, fosamprenavir + ritonavir Limit to 10/20 mg. Patient taking nelfinavir Limit to 10/40 mg.

Administration

May be taken with or without food.

Contraindications

Hypersensitivity. Active liver disease or unexplained persistent serum transaminase elevations exceeding 3 times ULN. Patients concomitantly treated w/ glecaprevir/pibrentasvir. Pregnancy & lactation.

MIMS Class

Dyslipidaemic Agents

ATC Classification

C10BA05 - atorvastatin and ezetimibe ; Belongs to the class of HMG CoA reductase inhibitors in combination with other lipid modifying agents. Used in the treatment of hyperlipidemia.

Regulatory Classification

POM

Presentation/Packing

Form

Atozet 10/10 mg FC tab

Packing/Price

1's

Form

Atozet 10/20 mg FC tab

Packing/Price

1's

Form

Atozet 10/40 mg FC tab

Packing/Price

1's

Form

Atozet 10/80 mg FC tab

Packing/Price

1's

Atozet

Manufacturer:

Organon