Cushing's syndrome eg, w/ moon face, truncal obesity, reduced glucose tolerance, DM, HTN, Na retention w/ oedema, increased K excretion, inactivity or atrophy of the adrenal cortex, red striae, steroid acne, disturbance of sex hormone secretion (eg, amenorrhoea, hirsutism, impotence); dyspepsia; increased risk of infection; muscle & joint pain, muscle weakness & twitching, osteoporosis; headache; depression, irritability, euphoria; allergic exanthema, petechiae, delayed wound healing, contact dermatitis; burning sensation in the rectum & pain.