Cystic fibrosis Adult & childn ≥4 yr Initially 500 lipase u/kg/meal, max: 2,500 lipase u/kg/meal (≤10,000 lipase u/kg/day or <4,000 lipase u/g fat/day);
childn >12 mth & <4 yr Initially 1,000 lipase u/kg/meal. Max: 2,500 lipase u/kg/meal (or ≤10,000 lipase u/kg/day or <4,000 lipase u/g fat/day).
Infant up to 12 mth 2,000-4,000 lipase u/120 mL of formula or per breastfeeding.
Other pancreatic exocrine insufficiency disorders Individualized dosage according to the degree of maldigestion & fat content of the meal. Required dosage range for a meal: 25,000-80,000 lipase u & ½ of individual dose for snacks.