Contraindications
Severe renal or hepatic failure; blood disorders; hypersensitivity to sulfonamides; acute porphyria; SLE. Pregnancy (3rd trimester) and lactation; infants ≤2 mth.
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Special Precautions
Renal or hepatic impairment; history of allergy or asthma; AIDS; G6PD deficiency; elderly; ensure adequate fluid intake to reduce risk of crystalluria. Discontinue use if rash occurs.
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Adverse Reactions
Nausea, vomiting, anorexia, diarrhoea; hypersensitivity reactions, SLE, serum sickness-like syndrome, liver necrosis and hepatomegaly, myocarditis, pulmonary eosinophilia and fibrosing alveolitis, vasculitis, hypoglycaemia, hypothyroidism, neurological reactions, jaundice and kernicterus in premature neonates. Pseudomembranous colitis.
Potentially Fatal: Stevens-Johnson syndrome, toxic epidermal necrolysis, blood dyscrasias, anaphylaxis. |
Drug Interactions
Potentiates effects of oral anticoagulants, methotrexate, phenytoin. Compounds that render urine acidic increase risk of crystalluria.
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Lab Interference
Interference with tests for urea, creatinine, urinary glucose, urobilinogen.
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Action
Description:
Mechanism of Action: Sulfadimethoxine is a long-acting sulfonamide which is used in veterinary medicine, sometimes in combination with baquiloprim or ormetoprim. It was formerly used in the treatment of UTI in humans. |
MIMS Class
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