Apalife

Aripiprazole

Schizophrenia & acute manic or mixed episodes. Maintenance treatment of bipolar I disorder. Adjunctive treatment of major depressive disorder (MDD), irritability associated w/ autistic disorder, agitation associated w/ schizophrenia or bipolar mania & Tourette's disorder.

Schizophrenia Initially 10-15 mg/day. Dose adjustment should not be made before 2 wk. Recommended dose: 10-15 mg/day. Max: 30 mg/day. Childn 13-17 yr Initially 2 mg/day, titrate to 5 mg/day after 2 days & to 10 mg/day after an additional 2 days. Subsequent dose increase in 5-mg increments. Recommended dose: 10 mg/day. Max: 30 mg/day. Bipolar I disorder, manic or mixed schizophrenia Initially 15 mg/day. Adjunct treatment: 10-15 mg/day. Recommended dose: 15 mg/day. Max: 30 mg. 10-17 yr Initially 2 mg/day, titrate to 5 mg/day after 2 days & to 10 mg/day after an additional 2 days. Subsequent dose increase in 5-mg increments. Recommended dose: 10 mg/day. Max: 30 mg/day. MDD Initially 2-5 mg/day, adjusted to 5 mg/day at intervals of no <1 wk. Recommended dose: 5-10 mg/day. Max: 15 mg/day. Irritability associated w/ autistic disorder 6-17 yr Initially 2 mg/day, adjusted to 5 mg/day at intervals of no less than 1 wk. Recommended dose: 5-10 mg/day. Max: 15 mg/day. Tourette's disorder 6-18 yr Initially 2 mg/day, adjusted to 5 mg/day at intervals of no <2 wk. Recommended dose: 2-20 mg/day. Max: 20 mg/day.

May be taken with or without food.

Hypersensitivity.

Patients w/ dementia-related psychosis. Increased risk of suicidality. NMS, tardive dyskinesia, hyperglycemia, DM, orthostatic hypotension, seizures/convulsions, dysphagia. May disrupt body's ability to reduce core body temp. May impair ability to drive or operate machinery. Pregnancy & lactation.

Nausea, vomiting, constipation, headache, dizziness, akathisia, anxiety, insomnia, restlessness, somnolence, extrapyramidal disorder, sedation, tremor, fatigue, blurred vision, salivary hypersecretion.

May enhance the effect of certain antihypertensives. Other centrally-acting drugs or alcohol, carbamazepine, ketoconazole, quinidine, fluoxetine or paroxetine.

Antipsychotics

N05AX12 - aripiprazole ; Belongs to the class of other antipsychotics.

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