Adult & elderly Initially 5 mg/day in the evening (prior to retiring). May be increased to 10 mg/day after at least 4-6 wk of clinical assessment in patients who tolerated treatment at 5 mg/day. Vascular dementia & DLB Max: 10 mg/day.
May exaggerate succinylcholine-type muscle relaxation during anesth. Patients w/ sick-sinus syndrome, supraventricular cardiac conduction conditions eg, SA or AV block, history of ulcer disease or those receiving concurrent NSAIDs; history of asthma or obstructive pulmonary disease. May exacerbate or induce extrapyramidal symptoms; cause bladder outflow obstruction. Avoid concomitant use w/ inhibitors of acetylcholinesterase, agonists or antagonists of the cholinergic system. Severe hepatic impairment. May affect ability to drive or operate machinery. Pregnancy & lactation. Not recommended for childn.
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