Essential HTN, heart failure & impaired left ventricle systolic function (LVEF ≤40%), as add-on therapy to ACE inhibitors or when ACE inhibitors are not tolerated.
Dosage/Direction for Use
HTN 8-32 mg once daily. Heart failure Initially 4 mg once daily, up-titration to the highest target dose 32 mg or tolerated dose by doubling the dose intervals of at least 2 wk.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity. Severe hepatic impairment &/or cholestasis. Pregnancy & lactation.