Colistate 150 Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Storage MIMS Class ATC Classification Thai FDA Category Presentation/Packing

Concise Prescribing Info

Contents

Colistin (equiv to colistimethate Na)

Indications/Uses

Infections due to sensitive strains of certain gm -ve bacilli which are resistant to other antibacterial (eg, Acinetobacter spp., Citrobacter spp., E. coli, Enterobacter spp., H. influenzae, Klebsiella pneumoniae, Pseudomonas aeruginosa, Salmonella spp., Shigella spp., & some strains of Bordetella spp. & Vibrio spp).

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Dosage/Direction for Use

2.5-5 mg/kg/day IV or IV infusion or IM in 2-4 divided doses depending upon the severity of the infection. Max: 5 mg/kg/day. Normal renal function (0.7-1.2 mg/dL creatinine & 80-100% urea clearance) 100-150 bid-qid. Approx daily dose: 5 mg/kg. Total daily dose: 300 mg. Mild renal impairment (1.3-1.5 mg/dL creatinine & 40-70% urea clearance) 75-115 mg bid. Approx daily dose: 2.5-3.8 mg/kg. Total daily dose: 150-230 mg. Moderate renal impairment (1.6-2.5 mg/dL creatinine & 25-40% urea clearance) 66-150 mg once daily or bid. Approx daily dose: 2.5 mg/kg. Total daily dose: 133-150 mg. Severe renal impairment (2.6-4 mg/dL creatinine & 10-25% urea clearance) 100-150 mg every 36 hr. Approx daily dose: 1.5 mg/kg. Total daily dose: 100 mg.

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Overdosage

View Colistate 150 overdosage for action to be taken in the event of an overdose.

Contraindications

Hypersensitivity.

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Special Precautions

Preexisting renal disease or elderly. May increase risk for neuromuscular blockade & apnea in impaired renal function. Transient, reversible neurological disturbances (eg, dizziness, numbness, paresthesia, tingling, & vertigo). Prolonged use may result in fungal or bacterial superinfection including C. difficile-associated diarrhea & pseudomembranous colitis. May impair ability to drive or operate machinery. Pregnancy & lactation.

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Use In Pregnancy & Lactation

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Adverse Reactions

Dizziness, fever, headache, slurred speech, vertigo; pruritus, rash, urticaria; GI upset; paresthesia (extremities, oral), weakness (lower limb); increased BUN, increased creatinine, nephrotoxicity, proteinuria, decreased urine output; apnea, resp arrest.

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Drug Interactions

Additive nephrotoxic &/or neurotoxic effects w/ aminoglycosides, amphotericin B, capreomycin, methoxyflurane, polymycin B sulfate, vancomycin). Potentiation of neuromuscular blockade w/ neuromuscular blocking agents eg, tubocurarine, succinylcholine, ether, decamethonium, gallamine & Na citrate.

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Storage

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Description

View Colistate 150 description for details of the chemical structure and excipients (inactive components).

Action

View Colistate 150 mechanism of action for pharmacodynamics and pharmacokinetics details.

MIMS Class

Other Antibiotics

ATC Classification

J01XB01 - colistin ; Belongs to the class of polymyxins. Used in the systemic treatment of infections.

Thai FDA Category

Presentation/Packing

Form

Colistate 150 powd for inj 150 mg

Packing/Price

10 × 1's;100 × 1's

Colistate 150

colistimethate sodium

Manufacturer:

Atlantic Lab

Distributor:

Atlantic Pharma