Short stature in childn due to growth hormone deficiency (GHD), Turner syndrome, born small for gestational age (SGA).
Dosage/Direction for Use
GHD 0.5 IU/kg/wk or 12 IU/m2 BSA/wk. Administer in the evening. Turner syndrome 1 IU/kg/wk. SGA 1.44 IU/kg/wk. All doses to be divided into 6-7 SC inj.
Contraindications
DM, malignant tumor, closed epiphyses, short stature due to brain tumor.
Special Precautions
Heart & kidney disease, maturity-onset diabetes or childn w/ familial history of DM. Examine progression of tumor in patients w/ intracranial lesion before initiation of therapy. Hyperglycemia & ketosis may occur. Hypothyroidism may inhibit effect. Monitor for overfiltration w/ increasing renal plasma flow & GFR. Pregnancy.
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