Methotrexat-Ebewe Dosage & Drug Information

Concise Prescribing Info

Contents

MTX

Indications/Uses

Acute lymphatic leukaemia, mammary, ovarian & bronchial carcinoma, chorion epithelioma, tumours of head & neck, testicular tumours, osteosarcoma, leukaemic meningo-encephalomyelopathy, refractory psoriasis vulgaris. Autoimmune diseases.

Dosage/Direction for Use

Tab Malignant tumors & haemoblastoses Individualized dosage. Psoriasis, psoriatic arthritis & autoimmunopathies Wkly dosage: 10-25 mg. Start w/ 2.5-7.5 mg, increased to 25 mg wkly. Divided oral dosage: 2.5 mg 12 hrly for 3 doses/wk. Vial Dilute to a soln containing 1-2% MTX. Dosage individually adapted to each patient. By IV infusion.

Contraindications

Pregnancy. Diseases of the hematopoietic system. Recent operation wounds.

Special Precautions

Infection, peptic ulcer, ulcerative colitis, debility & extreme youth & old age, liver & kidney dysfunction.

Adverse Reactions

Ulcerative stomatitis, leukopenia, thrombocytopenia, nausea & abdominal distress.

View ADR Monitoring Form

Drug Interactions

Folic acid. Salicylates, phenylbutazone, phenytoin, barbiturates, sulfonamides, corticosteroids, tetracyclines, chloramphenicol, PABA, p-aminohippuric acid or probenecid.

MIMS Class

Cytotoxic Chemotherapy

ATC Classification

L01BA01 - methotrexate ; Belongs to the class of antimetabolites, folic acid analogues. Used in the treatment of cancer.

Thai FDA Category

Presentation/Packing

Form

Methotrexat-Ebewe infusion 5000 mg/50 mL

Packing/Price

1's

Methotrexat-Ebewe

methotrexate

Manufacturer:

Sandoz

Distributor:

Zuellig Pharma

Marketer:

Novartis