Decreases ciclosporin levels: Barbiturates, carbamazepine, oxcarbazepine, phenytoin; nafcillin, sulfadimidine IV, rifampicin, octreotide, probucol, orlistat, St. John's wort, ticlopidine, sulfinpyrazone, terbinafine, bosentan. Increases ciclosporin levels: Macrolides, ketoconazole, fluconazole, itraconazole, voriconazole; diltiazem, nicardipine, verapamil; metoclopramide, OC, danazol, high-dose methylprednisolone, allopurinol, amiodarone, cholic acid & derivatives, PIs, imatinib, colchicine, nefazodone. Exhibits nephrotoxic synergy: Aminoglycosides, amphotericin B, ciprofloxacin, vancomycin, trimethoprim (+ sulfamethoxazole), NSAIDs (including diclofenac, naproxen, sulindac), melphalan, H
2-blockers, MTX, tacrolimus. May increase levels of drugs that are substrates of P-gp: Digoxin, colchicine, prednisolone, statins, etoposide, aliskiren, bosentan, dabigatran, everolimus, sirolimus. May increase level of both drugs: Lercanidipine. May significantly increase serum K. May increase rate of gingival hyperplasia: Nifedipine.