Sucralfate (D.C.I.) is a complex of Sucrose sulphate with aluminium hydroxide. Sucralfate Gel, contained in sucrate fel suspension, is an original patented physical form of sucralfate, owned by LISAPHARMA. Sucralfate Gel possesses a double specific surface area compared to the sucralfate poweder and shows a tenacious adhesiveness to the mucosae. This characteristic supports the anti-ulcer activity of the product.
Pharmacology: Pharmacodynamics: Only very small quantities of sucralfate are absorbed by the gastrointestinal tract and they are excreted by the urinary tract. Although the sucralfate mechanism of action in the process of healing gastroduodenal ulcers is not clarified yet, it is well demonstrated that it is due to a local action and not to a systemic one. In particular, as demonstrated by some studies of clinical pharmacology. Sucralfate binds to the ulcer through a complex with proteic exudate of the ulcerated area. These studies confirm the hypothesis that the anti-ulcer activity of sucralfate is due to the production of an adhering complex to the ulceration that protects it from further attacks of acids, pepsine and billiary salts. Since sucralfate's capacity of neutralizing acid is very modest, its anti-ulcer activity cannot be ascribed to a neutralization of gastric acidity.
Gastric ulcer, duodenal ulcer, acute and symptomatic chronic gastritis, non-erosive gastro-oesophageal reflux disease, acute radiation oesophagitis, preventing radiation-induced oral discomfort during and following radiotherapy, concomitantly used with NSAIDs therapy, prophylaxis of stress ulcer and recurrence.
The peculiar gel form of the product, for its characteristics of extended bioadhesivity, determines a sustained clinical effect and normally enables to administer the product twice per day. The usual posology is of 1 bag twice per day on an empty stomach, one hour before meals, or in the morning and at night before going to bed. For maintenance treatments, the daily posology is reduced to the half, keeping unchanged the single dose and reducing the assumption quantities to a half (for example 1 bag once per day preferably at night before going to bed). Each administration can be followed by a water or whatever liquid draught.
Known individual ascertained hypersensitivity to the drug. Do not administer Sucralfate during antibiotic treatments with tetracyclines, to avoid a build-up of complex salts with relative inactivation of antibiotics. As Sucralfate could modify the bioavailability of other drugs, allow at least a two hours' interval between the two administrations.
Use with precaution avoiding prolonged treatments, in patients with renal insufficiency. The use in pregnant women should be carefully considered and administered only if evidently necessary. The characteristic puckery sensation felt in the mouth upon intake of the drug is the peculiarity of the Sucralfate's gel form. To eliminate this aftertaste, it is enough to drink some water or any other liquid after the preparation administration.
The long term treatment may cause constipation. However, gastroenteric diseases, dry mouth, rash, itching, vertigo and insomnia have also been reported.
Keep at temperature not exceeding 35°C.
A02BX02 - sucralfate ; Belongs to the class of other drugs used in the treatment of peptic ulcer and gastro-oesophageal reflux disease (GERD).
Sucrate Gel oral gel 1000 mg
5 mL x 1's
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