Total vitamin C, ascorbic acid.
Each film-coated tablet contains: Total Vitamin C 1,000 mg, ascorbic acid 400 mg, sodium ascorbate 350 mg (equivalent to ascorbic acid 300 mg), calcium ascorbate 400 mg (equivalent to ascorbic acid 300 mg), citrus bioflavonoids extract 50 mg, Sophora japonica extract 50 mg, hesperidine 50 mg, rosehips extract 62.50 mg, accerola cherry extract 12.50 mg.
Pharmacology: Pharmacodynamics: Mechanism of action: Vitamin C (ascorbic acid) is a water-soluble vitamin with antioxidant properties. The vitamin is an essential coenzyme for collagen formation, tissue repair, and synthesis of lipids and proteins. It acts both as a reducing agent and as an antioxidant and is necessary for many physiological functions (e.g., metabolism of iron and folic acid, resistantace to infection, preservation of blood vessel integrity).
Pharmacokinetics: Ascorbic acid is normally present in both plasma and cells. The absorbed vitamin is ubiquitous in all body tissue. The highest concentration are found in granular tissue, the lowest in muscle and stored fat. A major route of metabolism of ascorbic acid involves its conversion to urinary oxalate, presumably through intermediate formation of its oxidized product, dehydroascorbic acid. Ascorbic acid is partially destroy and partially excreted by the body. There is a renal threshold for vitamin C; the vitamin is excreted by kidney in large amounts only when the plasma concentration exceeds this threshold, which is approximately 1.4 mg/100 ml.
Ascorbic acid deficiency.
Adult: Oral 1 tablet daily or as directed by the physician.
The recommended dose for the treatment of scurvy is 1 g administered orally for the first 2 days then 500 mg orally daily for a week.
Mode of Administration: Ascorbic acid is usually administered orally. When oral administration is not feasible or when malabsorption is suspected, administer IM, IV, or subcutaneously.
Nausea, vomiting, gout precipitation, rebound scurvy, increased iron absorption, impaired bacterial activity, and diarrhea. Monitor risk for developing renal calcium oxalate stones due to excessive oxalate excretion produced by ascorbic acid metabolism.
Hypersensitivity to any component of the preparation.
Diabetic patients, patients prone to recurrent renal calculi, those undergoing stool occult blood tests, and those on sodium-restricted diets or anticoagulant therapy should not take excessive doses of vitamin C over an extended period of time.
Ascorbic acid toxicity can also lead to hemolysis in patients deficient in glucose 6-phosphate dehydrogenase.
Use in Pregnancy: Category C (in doses greater than the RDA).
It is not known whether ascorbic acid can cause fetal harm or can affect reproduction capacity. Give to pregnant women only if clearly needed.
Use in Lactation: Administer with caution to a breast-feeding mother. Ascorbic acid is excreted in breast milk.
Hyperglycemia: High dose ascorbic acid (4500 mg/day) can cause elevation of plasma glucose.
Gastrointestinal Effects: Esophagitis and gastrointestinal obstruction have been rarely reported after ingestion of ascorbic acid.
Megadoses may cause nausea, stomach cramps, diarrhea, and nepholithiasis.
Acidification of the urine by ascorbic acid may cause precipitation of cysteine, urate, or oxalate stones and will alter the excretion of certain other drugs administered concurrently.
Concurrent use of large doses vitamin C and warfarin may interfere with the anticoagulant effect.
Concurrent administration of ascorbic acid and disulfiram will interfere with the effectiveness of disulfiram given to patients to encourage abstention from alcohol.
Concurrent administration of ascorbic acid and bishydroxycoumarin may influence the intensity and duration of action of bishydroxycoumarin.
Diabetic patients taking more than 500 mg/day ascorbic acid may obtain false readings of their urinary glucose test.
A11GA - Ascorbic acid (vitamin C), plain ; Used as dietary supplements.
Teddy Orange C 1000 tab 1,000 mg
5 × 6's
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