Chlorhexidine


Thông tin thuốc gốc
Chỉ định và Liều dùng
Mouth/Throat
Aphthous ulcer, Oral candidiasis, Oral hygiene
Adult: As chlorhexidine digluconate 0.2% spray: Apply bid. Max: 12 actuations bid. As chlorhexidine digluconate 1% gel: Brush teeth with 1 inch of gel once or bid for about 1 minute. As chlorhexidine digluconate 0.2% solution: Rinse mouth bid with 10 mL for about 1 minute or soak dentures for 15 minutes bid.
Child: ≥12 years Same as adult dose.

Mouth/Throat
Gingivitis
Adult: For treatment and prevention: As chlorhexidine digluconate 0.2% spray: Apply bid for 1 month. Max: 12 actuations bid. As chlorhexidine gluconate 0.12% solution: Rinse mouth bid with 15 mL for about 30 seconds. As chlorhexidine digluconate 0.2% solution: Rinse mouth bid with 10 mL for about 1 minute. As chlorhexidine digluconate 1% gel: Brush teeth with 1 inch of gel once or bid for about 1 minute for 1 month.
Child: ≥12 years Same as adult dose.

Mouth/Throat
Prophylaxis of dental caries
Adult: As chlorhexidine digluconate 1% gel: Apply for 5 minutes every night for 14 days in a close-fitting tray. Repeat treatment every 3-4 months.
Child: ≥12 years Same as adult dose.

Topical/Cutaneous
Antiseptic and disinfectant
Adult: As chlorhexidine acetate 0.05% solution: Irrigation of wound and burn. As chlorhexidine gluconate 4% solution: General cleansing of skin and wounds. As chlorhexidine gluconate 0.25% cream: Minor burns and abrasions.
Tương kỵ
Incompatible with soaps or other anionic agents.
Chống chỉ định
Hypersensitivity.
Thận trọng
Children. Pregnancy and lactation.
Tác dụng không mong muốn
Significant: Chemical burns in neonates.
Gastrointestinal disorders: Dry mouth, taste alteration.
Skin and subcutaneous tissue disorders: Dermatitis, pruritus, erythema, eczema, rash, urticaria, skin irritation, blisters.
Potentially Fatal: Serious allergic reactions (e.g. anaphylactic shock).
Mouth/Throat/Topical/Vag: B; Periodontal: C
Thông tin tư vấn bệnh nhân
Not intended for use in the eye, auditory canal, meninges, brain, spinal cord and genital area. This drug may stain teeth and tongue.
Tác dụng
Description:
Mechanism of Action: Chlorhexidine exerts its bactericidal activity against gram-positive and gram-negative organisms by binding cationic molecule to negatively charged bacterial cell walls and extramicrobial complexes leading to precipitation of cytoplasmic contents of bacterial cell wall which results in cell death. At low concentration, it acts as a bacteriostatic by alteration of bacterial cell osmotic equilibrium and leakage of potassium and phosphorus.
Pharmacokinetics:
Absorption: Poorly absorbed from gastrointestinal tract.
Excretion: Via faeces (approx 90%); urine (<1%).
Đặc tính

Chemical Structure Image
Chlorhexidine

Source: National Center for Biotechnology Information. PubChem Database. Chlorhexidine, CID=9552079, https://pubchem.ncbi.nlm.nih.gov/compound/Chlorhexidine (accessed on Jan. 21, 2020)

Bảo quản
Store below 25°C. Protect from light.
Phân loại MIMS
Thuốc dùng trong viêm & loét miệng / Thuốc khử trùng & sát trùng da
Phân loại ATC
R02AA05 - chlorhexidine ; Belongs to the class of antiseptics used in throat preparations.
A01AB03 - chlorhexidine ; Belongs to the class of local antiinfective and antiseptic preparations. Used in the treatment of diseases of the mouth.
B05CA02 - chlorhexidine ; Belongs to the class of antiinfectives used as irrigating solutions.
D08AC02 - chlorhexidine ; Belongs to the class of biguanide and amidine antiseptics. Used in the treatment of dermatological diseases.
Tài liệu tham khảo
Acclean Chlorhexidine Gluconate 0.12% Oral Rinse. DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 07/03/2019.

Anon. Chlorhexidine Gluconate (Oral). Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 07/03/2019.

Anon. Chlorhexidine Gluconate (Topical). Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 07/03/2019.

Antiseptic Skin Cleanser- Chlorhexidine Gluconate 4% Liquid (Chain Drug Consortium, LLC). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 11/03/2019.

Buckingham R (ed). Chlorhexidine. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 07/03/2019.

Chlorhexidine. Gold Standard Drug Database in ClinicalKey [online]. Elsevier Inc. https://www.clinicalkey.com/. Accessed 07/03/2019.

Joint Formulary Committee. Chlorhexidine. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 07/03/2019.

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