Adult: As 1% cream: Apply thinly and evenly to the affected area bid and rub in gently. Max duration: 7 days. Max: 10 mg/kg; 500 mg for 50 kg adult equivalent to approx 2 cm to be divided into 2 applications per day. Elderly: Use minimum quantity for the shortest duration. Child: Require shorter course of treatment.
Chống chỉ định
Hypersensitivity. Use on broken skin. Diseases affecting the skin (e.g. acne, perioral dermatitis); any untreated bacterial skin diseases; viral skin diseases (e.g. herpes simplex, chicken pox); dermal vaccination reactions.
Thận trọng
Elderly, childn and infant. Pregnancy and lactation.
Do not apply on large areas (>5-10% of the body surface), under occlusive dressings (e.g. nappies and bandages). Do not use in long-term continuous therapy. May damage latex contraceptives.
Tương tác
May reduce effectiveness of contraceptives.
Tác dụng
Description: Mechanism of Action: Clotrimazole inhibits ergosterol synthesis, which leads to structural and functional impairment of fungal cytoplasmic membrane. Hydrocortisone, a weak corticosteroid w/ both glucocorticoid and to a lesser extent mineralocorticoid activity, has antiphlogistic, antipruriginous, antiexudative and antiallergic effects. Pharmacokinetics: Absorption: Clotrimazole: Penetrates the epidermis w/ a little systemic absorption. Absorbed 3-10% of a dose (vag use). Hydrocortisone: Absorbed through the skin particularly in denuded areas. Distribution: Hydrocortisone: Plasma protein binding: >90%. Metabolism: Clotrimazole: Hepatically metabolised to inactive compounds. Hydrocortisone: Metabolised in the liver and tissues. Excretion: Clotrimazole: Via faeces and urine. Hydrocortisone: Via urine. Biological half-life: Approx 100 min.
Đặc tính
Clotrimazole Source: National Center for Biotechnology Information. PubChem Database. Clotrimazole, CID=2812, https://pubchem.ncbi.nlm.nih.gov/compound/Clotrimazole (accessed on Jan. 21, 2020)
Hydrocortisone Source: National Center for Biotechnology Information. PubChem Database. Hydrocortisone, CID=5754, https://pubchem.ncbi.nlm.nih.gov/compound/Hydrocortisone (accessed on Jan. 21, 2020)
D01AC - Imidazole and triazole derivatives ; Used in the topical treatment of fungal infection.
Tài liệu tham khảo
Buckingham R (ed). Clotrimazole. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 08/03/2016.Buckingham R (ed). Hydrocortisone. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 08/03/2016.Joint Formulary Committee. Hydrocortisone with Clotrimazole. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 08/03/2016.
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