Ophthalmic Mydriasis and cycloplegia for refraction
Adult: As 0.5, 1, or 2% soln: Instill 1 drop to each eye 30-60 min prior to procedure, may repeat after 5-15 min if necessary. Deeply pigmented eyes may require higher strength. Apply pressure over the nasolacrimal sac for 2-3 min after instillation to minimize absorption. Child: As 0.5 or 1% soln: 3 mth to 12 yr Instill 1 drop of 1% soln to each eye 30-60 min prior to procedure; >12 yr Instill 1 drop of 0.5% soln to each eye 30-60 min prior to procedure, may repeat after 5-10 min if necessary. Apply pressure over the nasolacrimal sac for 2-3 min after instillation to minimize absorption. Observe for 45 min after instillation.
Ophthalmic Iritis, Uveitis
Adult: As 0.5 or 1% soln: Instill 1 drop onto the affected eye(s) 6-8 hrly. Deeply pigmented eyes may require higher strength. Child: ≥3 mth Same as adult dose.
Chống chỉ định
Confirmed or suspected narrow-angle glaucoma.
Thận trọng
Patient w/ Down syndrome. Debilitated patients. Childn w/ spastic paralysis or brain damage. Pregnancy and lactation.
Tác dụng không mong muốn
Significant: Transient increase in intraocular pressure, ocular irritation and burning sensation, CNS disturbance, psychotic reactions. Nervous: Insomnia, drowsiness, ataxia, hallucination, hyperactivity, incoherent speech, restlessness, seizure. CV: Tachycardia. Ophthalmologic: Accommodation disturbance, intolerance to bright light, stinging, blurring of vision, punctal stenosis. Dermatologic: Burning sensation of the skin.
This drug may cause transient blurring of vision and increased sensitivity to light, if affected, do not drive or operate machinery. Remove contact lenses prior to admin and reinsert after 15 min.
Chỉ số theo dõi
Perform tonometric examination prior to use of drug.
May interfere w/ ocular antihypertensive action of carbachol, pilocarpine, or ophthalmic cholinesterase inhibitors.
Tác dụng
Description: Mechanism of Action: Cyclopentolate is a tertiary amine antimuscarinic agent. It reversibly blocks the action of acetylcholine resulting in relaxation of innervated iris sphincter muscle producing mydriasis. Additionally, it also paralyzes the ciliary muscle of the lense producing cycloplegia. Onset: Max: Mydriasis: Approx 30-60 min. Cycloplegia: 25-75 min. Duration: Mydriasis: Approx 24 hr. Cycloplegia: 6-24 hr. Pharmacokinetics: Absorption: May be systemically absorbed by transcorneal absorption.
Đặc tính
Cyclopentolate Source: National Center for Biotechnology Information. PubChem Database. Cyclopentolate, CID=2905, https://pubchem.ncbi.nlm.nih.gov/compound/Cyclopentolate (accessed on Jan. 22, 2020)
Bảo quản
Store between 20-25°C. Protect from light. Do not freeze.
S01FA04 - cyclopentolate ; Belongs to the class of anticholinergics used as mydriatics and cycloplegics.
Tài liệu tham khảo
Anon. Cyclopentolate. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 05/07/2017.Buckingham R (ed). Cyclopentolate Hydrochloride. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 05/07/2017.Cyclopentolate Solution/Drops (Akorn, Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 05/07/2017.Joint Formulary Committee. Cyclopentolate Hydrochloride. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 05/07/2017.McEvoy GK, Snow EK, Miller J et al (eds). Cyclopentolate Hydrochloride (EENT). AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 05/07/2017.
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