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Chỉ định và Liều dùng
Oral
Osteoarthritis of the knee Adult: Monotherapy or adjunctive treatment for the symptomatic relief of mild to moderate cases: As glucosamine hydrochloride tab/effervescent tab/cap: Usual dose: 1,250 mg once daily, as a single dose or in 2 divided doses. As glucosamine sulfate tab/powder for oral solution: Usual dose: 1,500 mg once daily, as a single dose or in 2-3 divided doses. Re-evaluate treatment if relief of symptoms is not achieved after 2-3 months.
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Cách dùng
Should be taken with food. Preferably taken at meals.
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Hướng dẫn pha thuốc
Effervescent tab: Dissolve in at least 100 mL of water. Powder for oral solution: Dissolve in at least 250 mL of water.
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Chống chỉ định
Hypersensitivity to glucosamine and shellfish. Children.
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Thận trọng
Patient with impaired glucose tolerance, diabetes mellitus, asthma; known risk factors for CV disease. Rule out the presence of other joint diseases. Not indicated for the treatment of acute painful symptoms. Renal and hepatic impairment. Pregnancy and lactation.
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Tác dụng không mong muốn
Significant: Asthma exacerbation, hypercholesterolaemia, worsened blood glucose control.
Gastrointestinal disorders: Nausea, vomiting, diarrhoea, constipation, abdominal pain, heartburn, flatulence, dyspepsia. General disorders and administration site conditions: Fatigue, peripheral oedema. Hepatobiliary disorders: Jaundice. Investigations: Elevated hepatic enzymes. Nervous system disorders: Headache, dizziness, drowsiness. Skin and subcutaneous tissue disorders: Rash, pruritus, erythema, urticaria. Vascular disorders: Flushing. |
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Thông tin tư vấn bệnh nhân
This drug may cause dizziness or drowsiness, if affected, do not drive or operate machinery.
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Chỉ số theo dõi
Monitor blood glucose levels prior to and periodically thereafter (in patients with impaired glucose tolerance); cholesterol levels (in at risk for CV disease).
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Quá liều
Symptoms: Headache, vertigo, dizziness, disorientation, arthralgia, nausea, vomiting, diarrhoea, and constipation. Management: Supportive treatment.
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Tương tác
May increase the anticoagulant effects of warfarin and acenocoumarol. May increase the absorption and serum levels of tetracyclines.
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Tác dụng
Description:
Mechanism of Action: Glucosamine is a natural substance found in mucoproteins, chitin, and mucopolysaccharides. It stimulates the synthesis of glycosaminoglycans which are responsible for the formation of cartilage in the body. It may be used as a health supplement in the management of musculoskeletal and joint disorders for its supposed chondroprotective activity. Pharmacokinetics: Distribution: Volume of distribution: Approx 2.5-5 L. Metabolism: Extensively metabolised in the liver. Excretion: Via urine. |
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Đặc tính
 Source: National Center for Biotechnology Information. PubChem Database. D-Glucosamine, CID=439213, https://pubchem.ncbi.nlm.nih.gov/compound/D-Glucosamine (accessed on Jan. 22, 2020) |
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Bảo quản
Store below 30°C. Protect from light and moisture.
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Phân loại MIMS
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Phân loại ATC
M01AX05 - glucosamine ; Belongs to the class of other non-steroidal antiinflammatory and antirheumatic products.
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Tài liệu tham khảo
Alateris 625 mg Tablets (Laboratoires Expanscience). MHRA. https://products.mhra.gov.uk/. Accessed 08/05/2020. Anon. Glucosamine. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 08/05/2020. Arthriex 750 mg Film-Coated Tablets (TSI Health Sciences [Europe] Ltd). MHRA. https://products.mhra.gov.uk/. Accessed 08/05/2020. Buckingham R (ed). Glucosamine. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 08/05/2020. Dolenio 500 mg Film-Coated Tablets (Blue Bio Pharmaceuticals Ltd). MHRA. https://products.mhra.gov.uk/. Accessed 08/05/2020. Dyna-RH Capsule (Dynapharm [M] Sdn. Bhd.). National Pharmaceutical Regulatory Agency - Ministry of Health Malaysia. https://www.npra.gov.my/. Accessed 19/05/2020. Gluco-S 1500 Powder for Oral Solution (MD Pharmaceuticals Pte Ltd). MIMS Singapore. http://www.mims.com/singapore. Accessed 08/05/2020. Glucosamine 1,250 mg Effervescent Tablets (Medley Pharma Limited). MHRA. https://products.mhra.gov.uk/. Accessed 19/05/2020. Glusartel 1,500 mg Powder for Oral Solution (Mylan Products Ltd.). MHRA. https://products.mhra.gov.uk/. Accessed 08/05/2020. Joint Formulary Committee. Glucosamine. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 08/05/2020. Yointy 625 mg Hard Capsules (Bioiberica S.A.U.). MHRA. https://products.mhra.gov.uk/. Accessed 08/05/2020.
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