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Chỉ định và Liều dùng
Ophthalmic
Mydriasis Adult: As hydrochloride: Instil in the eye as 2% eye drops. Oral Mild heart failure Adult: 100-200 mg bid-tid.
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Chống chỉ định
Oral: Severe heart failure, phaeochromocytoma. Ophthalmic: Angle-closure glaucoma.
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Thận trọng
CV diseases; hyperthyroidism; DM; elderly; pregnancy, lactation; prostate disorders; occlusive vascular disease; cardiac arrhythmias.
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Tác dụng không mong muốn
Palpitations, tachycardia, arrhythmias, reflex bradycardia. Hypotension, dizziness, fainting. Anxiety, fear, restlessness, insomnia, confusion, irritability, headache, psychotic symptoms. Dyspnoea, weakness, anorexia, nausea, vomiting. Mydriasis, difficulty in micturition and urinary retention, piloerection, sweating, increased salivation. Hyperglycaemia. Hypokalaemia and muscle tremor.
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Tương tác
Increased cardiac effects with volatile anaesthetics, thyroid hormones, cardiac glycosides and antiarrhythmics. Additive hypotensive effects with antihypertensives. Severe hypotension may occur with guanethidine. Increased risk of hypotension and tachycardia with α-blockers. Increased risk of hypertension with nonselective β-beta blockers. Increased risk of hypertension and arrhythmias with TCAs. Additive CV toxicity with levodopa, bromocriptine.
Potentially Fatal: Increased risk of mortality with amiodarone (although interaction is not established). |
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Tác dụng
Description:
Mechanism of Action: Ibopamine is a peripheral dopamine agonist with vasodilating properties and a weak positive inotropic effect. It stimulates α- and β-adrenoceptors at high concentrations. Pharmacokinetics: Absorption: Peak plasma concentrations after 30 min (oral). Metabolism: Rapidly converted to epinene (active metabolite) by esterase hydrolysis. |
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Phân loại MIMS
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Đăng xuất
