|
Chỉ định và Liều dùng
Oral
Disorders associated with reduced gastrointestinal motility Adult: For the management of gastrointestinal symptoms including the feeling of swollen abdomen, early satiety, postprandial fullness, upper abdominal pain or discomfort, nausea and vomiting, anorexia, and heartburn; non-ulcer dyspepsia: 50 mg tid. May reduce dose depending on the patient's age and symptoms.
|
|
Chống chỉ định
Conditions when increased gastrointestinal motility may be harmful (e.g. gastrointestinal haemorrhage, mechanical obstruction or perforation).
|
|
Thận trọng
Elderly. Pregnancy and lactation.
|
|
Tác dụng không mong muốn
Significant: May cause cholinergic effects.
Gastrointestinal disorders: Abdominal pain, diarrhoea, salivary hypersecretion. Investigations: Increased ALT, decreased WBC count. Nervous system disorders: Dizziness, headache. Skin and subcutaneous tissue disorders: Rash. |
|
Tương tác
May reduce activity with anticholinergic agents.
|
|
Tác dụng
Description:
Mechanism of Action: Itopride is a gastroprokinetic agent. It increases acetylcholine concentrations by antagonising dopamine D2 receptors and inhibiting acetylcholinesterase, thereby promoting gastrointestinal motility. Pharmacokinetics: Absorption: Rapidly and almost completely absorbed from the gastrointestinal tract. Bioavailability: 60%. Time to peak plasma concentration: 0.5-0.75 hours. Distribution: Plasma protein binding: Approx 96%, mainly to albumin. Metabolism: Extensively metabolised in the liver mainly via flavine monooxygenase enzymes. Excretion: Via urine. Terminal elimination half-life: Approx 6 hours. |
|
Đặc tính
 Source: National Center for Biotechnology Information. PubChem Database. Itopride, CID=3792, https://pubchem.ncbi.nlm.nih.gov/compound/Itopride (accessed on Jan. 21, 2020) |
|
Bảo quản
Store below 30°C. Protect from light and moisture.
|
|
Phân loại MIMS
|
|
Phân loại ATC
A03FA07 - itopride ; Belongs to the class of propulsives. Used in the treatment of functional gastrointestinal disorders.
|
|
Tài liệu tham khảo
Anon. Itopride. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 14/04/2021. Buckingham R (ed). Itopride Hydrochloride. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 14/04/2021. Elthon 50 mg Tablets (Abbott Laboratories Ltd.). MIMS Thailand. http://www.mims.com/thailand. Accessed 14/04/2021. Ganaton 50 mg Tablets (Abbott Laboratories [M] Sdn. Bhd.). National Pharmaceutical Regulatory Agency - Ministry of Health Malaysia. https://www.npra.gov.my. Accessed 14/04/2021. Progit 50 mg Tablets (PharmEng Technology Sdn. Bhd.). National Pharmaceutical Regulatory Agency - Ministry of Health Malaysia. https://www.npra.gov.my. Accessed 14/04/2021.
|
Đăng xuất
