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Chỉ định và Liều dùng
Oral
Postpartum haemorrhage Adult: During the puerperium: 0.2 mg 3 or 4 times daily for 1 week. Parenteral Postpartum haemorrhage Adult: After delivery of the anterior shoulder or placenta, or during the puerperium: 0.2 mg via IM inj. Doses may be repeated every 2-4 hours as necessary. In emergencies, the same dose may be given via slow IV infusion over 1 minute.
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Chống chỉ định
Hypersensitivity, hypertension, preeclampsia. Pregnancy.
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Thận trọng
Patient with sepsis, coronary artery disease (CAD), obliterative vascular disease. Use during the second stage of labour. Renal and hepatic impairment. Lactation.
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Tác dụng không mong muốn
Significant: Hypertension, myocardial ischaemia, MI; ergotism, pleural fibrosis, retroperitoneal fibrosis (prolonged use).
Cardiac disorders: Chest pain, bradycardia, tachycardia, palpitation, coronary arterial spasm. Ear and labyrinth disorders: Tinnitus. Gastrointestinal disorders: Nausea, vomiting, diarrhoea, abdominal pain. Immune system disorders: Anaphylaxis. Metabolism and nutrition disorders: Water intoxication. Musculoskeletal and connective tissue disorders: Leg cramps. Nervous system disorders: Dizziness, headache, dysgeusia, seizure. Psychiatric disorders: Hallucination. Renal and urinary disorders: Haematuria. Respiratory, thoracic and mediastinal disorders: Dyspnoea, nasal congestion. Skin and subcutaneous tissue disorders: Rash, diaphoresis. Vascular disorders: Vasoconstriction, vasospasm, thrombophlebitis, hypotension. |
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IM/IV/Parenteral/PO: C
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Chỉ số theo dõi
Monitor blood pressure, CNS status, and vaginal bleeding.
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Quá liều
Symptoms: Nausea, vomiting, abdominal pain, oliguria, tingling of the extremities, high blood pressure; hypotension, respiratory depression, hypothermia, convulsions. Management: Symptomatic and supportive treatment. Remove offending drug by inducing emesis, gastric lavage, catharsis, or supportive diuresis. Maintain adequate pulmonary ventilation, especially if convulsion or coma develop. Use standard anticonvulsant agents to control convulsion. Correct hypotension with pressor drugs. Treat peripheral vasospasm by applying warmth to the extremities as necessary.
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Tương tác
Increased risk of ergot toxicity with CYP3A4 inhibitors (e.g. erythromycin, clarithromycin, ritonavir, delavirdine, ketoconazole, itraconazole, voriconazole). Enhance vasoconstrictive effect with β-blockers. Diminished therapeutic effect with anaesthetics (e.g. halothane, methoxyflurane). Reduced therapeutic effect of glyceryl trinitrate and other antianginal medications.
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Tác dụng
Description:
Mechanism of Action: Methylergometrine is an ergot alkaloid. It increases the tone, rate and amplitude of uterine contractions which shortens the third stage of labour and reduces blood loss. Synonym: methylergonovine. Onset: 5-10 minutes (oral); 2-5 minutes (IM). Duration: Approx 3 hours (oral/IM). Pharmacokinetics: Absorption: Rapidly absorbed. Bioavailability: 60% (oral); 78% (IM). Time to peak plasma concentration: 0.3-2 hours (oral); 0.2-0.6 hours (IM). Distribution: Enters breast milk. Volume of distribution: 39-73 L. Metabolism: Undergoes extensive first-pass hepatic metabolism. Excretion: Via the urine and faeces. Elimination half-life: Approx 3 hours. |
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Đặc tính
 Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 8226, Methylergonovine. https://pubchem.ncbi.nlm.nih.gov/compound/Methylergonovine. Accessed Oct. 27, 2020. |
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Bảo quản
Tab: Store between 20-25°C. Inj: Store between 2-8°C. Protect from light.
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Phân loại MIMS
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Phân loại ATC
G02AB01 - methylergometrine ; Belongs to the class of ergot alkaloids. Used to induce abortion or augment labour and to minimize blood loss from the placental site.
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Tài liệu tham khảo
Anon. Methylergonovine. AHFS Clinical Drug Information [online]. Bethesda, MD. American Society of Health-System Pharmacists, Inc. https://www.ahfscdi.com. Accessed 02/09/2020. Anon. Methylergonovine. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 02/09/2020. Buckingham R (ed). Methylergometrine Maleate. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 02/09/2020. Methylergonovine Maleate Injection (Breckenridge Pharmaceuticals, Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 02/09/2020. Methylergonovine Tablet (Amneal Pharmaceuticals NY LLC). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 02/09/2020. Methylergonovine. Gold Standard Drug Database in ClinicalKey [online]. Elsevier Inc. https://www.clinicalkey.com/. Accessed 02/09/2020.
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