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Chỉ định và Liều dùng
Oral
Prophylaxis of migraine Adult: 50-100 mg daily. Oral Angina pectoris, Hypertension Adult: 50-100 mg once daily.
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Suy thận
Dosage adjustments may be required.
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Chống chỉ định
Hypersensitivity, 2nd and 3rd degree heart block, cardiogenic shock, bronchospasm, history of obstructive airway disease, metabolic acidosis, hypotension, severe peripheral arterial disease, sinus bradycardia.
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Thận trọng
Renal failure, DM, children, pregnancy and lactation. May mask symptoms of hyperthyroidism and hypoglycaemia. Avoid abrupt withdrawal.
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Tác dụng không mong muốn
Fatigue, cold extremities, bradycardia, heart failure, headache, dizziness, hallucinations, confusion and sleep disturbances.
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Quá liều
May cause severe and fatal CV depression. Activated charcoal or gastric lavage may be considered if patient presents within 1 hr of ingestion.
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Tương tác
Disopyramide when given in combination with atenolol depresses myocardial contractility and may precipitate cardiac failure. Efficacy may be antagonised by NSAIDs.
Potentially Fatal: Concurrent use with verapamil may precipitate heart failure in patients with impaired left ventricular function. Simultaneous withdrawal of atenolol and clonidine may result in severe rebound hypertension. |
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Tác dụng
Description:
Mechanism of Action: S-Atenolol selectively blocks the β1 receptors, and it significantly reduces both maximal and submaximal exercise heart rates in a dose-related manner. Endocrine and metabolic actions of S-atenolol include lowering of plasma renin activity and free fatty acids. |
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Phân loại MIMS
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Đăng xuất
