Sulodexide

Intramuscular, Intravenous
Cerebrovascular disease, Deep vein thrombosis, Diabetic nephropathy, Diabetic neuropathy, Diabetic retinopathy, Myocardial infarction, Peripheral arterial occlusive disease, Transient ischaemic attack, Venous leg ulcer

Oral
Cerebrovascular disease, Deep vein thrombosis, Diabetic nephropathy, Diabetic neuropathy, Diabetic retinopathy, Myocardial infarction, Peripheral arterial occlusive disease, Transient ischaemic attack, Venous leg ulcer

Should be taken on an empty stomach.

Hypersensitivity to heparin and heparinoids. Haemorrhagic disease or diathesis. Pregnancy.

Gastrointestinal disorders: Diarrhoea, nausea, vomiting, epigastralgia.
General disorders and administration site conditions: Burning sensation, pain and haematoma at inj site.

Monitor haemocoagulative parameters periodically.

May increase the anticoagulation effects of heparin and oral anticoagulants.

Description:
Mechanism of Action: Sulodexide is a sulfated polysaccharide complex consisting of 80% low molecular weight heparin and 20% dermatan sulfate. It exerts its antithrombotic activity through dose-dependent inhibition of activated coagulation factor X, as well as inhibition of platelet aggregation and activation of the circulating and parietal fibrinolytic system. Sulodexide also normalises the viscosimetric parameters that are usually altered in patients with vascular pathologies with thrombotic risk, mainly by reducing fibrinogen levels.
Pharmacokinetics:
Absorption: Rapidly absorbed. Bioavailability: 20-60%. Time to peak plasma concentration: 4 hours (oral).
Distribution: Widely distributed, particularly in the monocellular endothelial layer.
Metabolism: Metabolised in the liver.
Excretion: Mainly via urine (55.3 ± 2.9%); bile (23.5 ± 2.3%) and faeces (23.5 ± 2.8%). Elimination half-life: 18.7 ± 4. 1 hours (50 mg dose); 25.8 ± 1.9 hours (100 mg dose).

Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 6453528, Sulodexide. https://pubchem.ncbi.nlm.nih.gov/compound/6453528. Accessed July 28, 2022.

Store below 25°C.

Thuốc kháng đông, chống kết dính tiểu cầu & tiêu sợi huyết

B01AB11 - sulodexide ; Belongs to the class of heparin group. Used in the treatment of thrombosis.

Angioflux 250 LSU Softgel Capsule (Aesculapius Farmaceutici S.r.l.). MIMS Philippines. http://www.mims.com/philippines. Accessed 29/06/2022.

Anon. Sulodexide. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 29/06/2022.

Buckingham R (ed). Sulodexide. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 29/06/2022.

Vessel (Alfasigma S.p.A). MIMS Thailand. http://www.mims.com/thailand. Accessed 29/06/2022.

Vessel Due F (AlfaSigma). MIMS Malaysia. http://www.mims.com/malaysia. Accessed 29/06/2022.

Vessel Due F 250 LSU Capsule (EP Plus Group Sdn. Bhd.). National Pharmaceutical Regulatory Agency - Ministry of Health Malaysia. https://www.npra.gov.my. Accessed 29/06/2022.

Vessel Due-F (AlfaSigma). MIMS Philippines. http://www.mims.com/philippines. Accessed 29/06/2022.