Women Commence treatment on the 1st day of the cycle. Women w/ amenorrhoea or very irregular menstrual bleeding can start immediately. Women should receive a progestogen-oestrogen containing prep.
Hirsutism secondary to female androgenization Initially 1 tab (50 mg) daily for 10 days mthly, may be reduced once a satisfactory response has been attained. Maintenance therapy: 10 mg daily for 10 days mthly.
Other severe signs of androgenization 2 tab daily from 1st to 10th day of the cycle.
Postmenopausal or hysterectomised women ½-1 tab once daily for 21 days, followed by a 7-day tab-free interval. May be administered alone.
Men Max daily dose: 300 mg.
Reduction of drive in sexual deviations Initially 1 tab bd, if necessary may be increased to 2 tab bd-tds for a short period of time. When establishing maintenance dose or discontinuing the prep, reduce daily dose by 1 or ½ tab at intervals of several wk.
To reduce initial increase of male sex hormones in treatment w/ LH-RH agonists Initially 100 mg (2 tab) bd alone for 5-7 days, then 100 mg (2 tab) bd for 3-4 wk together w/ an LH-RH agonist.
In long-term palliative treatment of advanced prostate cancer w/o orchiectomy 100 mg (2 tab) bd-tds.
To treat hot flushes in patients under treatment w/ LH-RH analogues or who have had orchiectomy 50 mg (1 tab) once daily-tds, titrated to 100 mg (2 tab) tds if necessary.
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