Search

Coralan心健朗

Coralan

ivabradine

Manufacturer:

Servier

Distributor:

Zuellig
/
Agencia Lei Va Hong
Concise Prescribing Info
Contents
Ivabradine
Indications/Uses
Symptomatic treatment of chronic stable angina pectoris in CAD in adults w/ normal sinus rhythm who are unable to tolerate or w/ contraindication to use of β-blockers; in combination w/ β-blockers in patients inadequately controlled w/ an optimal β-blocker dose whose heart rate is >70 bpm. Treatment of chronic heart failure (NYHA class II-IV) w/ systolic dysfunction in combination w/ standard therapy including β-blocker therapy or when β-blocker is contraindicated or not tolerated in patients in sinus rhythm & whose heart rate is ≥75 bpm.
Click to view Coralan detailed prescribing information
Dosage/Direction for Use
Initially 5 mg bd for 3-4 wk, followed by up-titration to target dose 7.5 mg bd depending on the therapeutic response. Reduce dose to 2.5 mg bd if heart rate decreases to <50 bpm or symptoms of bradycardia is present.
Click to view Coralan detailed prescribing information
Overdosage
View Coralan overdosage for action to be taken in the event of an overdose.
Administration
Should be taken with food: Avoid excessive consumption of grapefruit juice.
Contraindications
Hypersensitivity. Resting heart rate <70 beats/min prior to treatment, cardiogenic shock, acute MI, severe hypotension (<90/50 mmHg), severe hepatic insufficiency, sick sinus syndrome, SA block, unstable or acute heart failure, pacemaker-dependent patient, unstable angina, 3rd degree AV-block. Concomitant w/ strong CYP3A4 inhibitors eg, azole antifungals, macrolides, HIV protease inhibitors & nefazodone; concomitant w/ verapamil or diltiazem (moderate CYP3A4 inhibitors w/ heart-rate reducing properties). Severe hepatic insufficiency. Women of childbearing potential not using appropriate contraceptive measures. Pregnancy & lactation.
Click to view Coralan detailed prescribing information
Warnings
For additional cautionary notes to warn of the potential risk of using the medicine... Click to view Coralan detailed prescribing information
Special Precautions
Atrial fibrillation, 2nd degree AV block, chronic heart failure, stroke, retinitis pigmentosa; galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption (due to lactose content). Hypotension, HTN, congenital QT syndrome, moderate hepatic impairment, CrCl <15 mL/min. Concomitant w/ verapamil or diltiazem. May affect ability to drive or operate machinery. Childn <18 yr.
Click to view Coralan detailed prescribing information
Adverse Reactions
Luminous phenomena (phosphenes), headache, dizziness, blurred vision, bradycardia, 1st degree AV block, ventricular extrasystoles, uncontrolled BP.
Click to view Coralan detailed prescribing information
Drug Interactions
QT-prolonging drugs. CYP3A4 inhibitors (eg, azole antifungals, macrolides, HIV-protease inhibitors, nefazodone, diltiazem & verapamil) & inducers (eg, rifampicin, barbiturates, phenytoin, St. John's wort). Grapefruit juice; K-depleting diuretics.
Click to view Coralan detailed prescribing information
Storage
View Coralan storage conditions for details to ensure optimal shelf-life.
Description
View Coralan description for details of the chemical structure and excipients (inactive components).
Action
View Coralan mechanism of action for pharmacodynamics and pharmacokinetics details.
MIMS Class
Anti-Anginal Drugs / Other Cardiovascular Drugs
ATC Classification
C01EB17 - ivabradine ; Belongs to the class of other cardiac preparations.
Presentation/Packing
Form
Coralan FC tab 5 mg
Packing/Price
56's
Form
Coralan FC tab 7.5 mg
Packing/Price
56's
Exclusive offer for doctors
Register for a MIMS account and receive free medical publications worth $768 a year.
Already a member? Sign in
Exclusive offer for doctors
Register for a MIMS account and receive free medical publications worth $768 a year.
Already a member? Sign in