A 0, 1 & 6 mth schedule gives optimal protection. An accelerated schedule, w/ immunisation at 0, 1 & 2 mth, will confer quick protection but requires 4th dose at 12 mth.
Adult & childn ≥16 yr 20 mcg IM in the deltoid region.
Neonate, infant & childn ≤15 yr 10 mcg IM in the anterolateral thigh.
Adult ≥18 yr requiring rapid induction of protection eg, person travelling to areas of high endemicity & who commence a course of vaccination against HBV w/in 1 mth prior to departure A schedule of 3 IM inj given at 0, 7 & 21 days may be used; 4th dose is recommended 12 mth after the 1st dose.
Childn 11-15 yr 20 mcg vaccine may be administered at 0, 6 mth schedule when there is low risk of HBV infection & when completion of 2-dose vaccination course can be assured. If both conditions cannot be assured (eg, patients undergoing haemodialysis, travellers to endemic regions & close contacts of infected subjects), 3-dose or the accelerated schedule of 10 mcg vaccine should be used.
Patient w/ renal insufficiency & undergoing haemodialysis ≥16 yr 4 double doses (2 x 20 mcg) at elected date, 1, 2 & 6 mth from date of 1st dose;
≤15 yr & neonates 10 mcg at either 0, 1, 2, & 12 mth or the 0, 1, 6 mth schedule.
Known or presumed exposure to HBV 1st dose can be administered simultaneously w/ HBIg at separate inj site at 0, 1, 2-12 mth immunisation schedule.
Neonate born of mother who is HBV carrier 10 mcg to start at birth w/ either 0, 1, 2 & 12 mth or the 0, 1 & 6 mth schedule. When available, HBIg should be given simultaneously.
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