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Humira has been studied in rheumatoid arthritis, polyarticular juvenile idiopathic arthritis and psoriatic arthritis patients taking Humira as monotherapy and those taking concomitant methotrexate. Antibody formation was lower when Humira was given together with methotrexate in comparison with use as monotherapy. Administration of Humira without methotrexate resulted in increased formation of antibodies, increased clearance and reduced efficacy of adalimumab (see Pharmacology: Pharmacodynamics under Actions).
The combination of Humira and anakinra is not recommended (see Concurrent administration of biologic DMARDs or TNF-antagonists under Precautions).
The combination of Humira and abatacept is not recommended (see Concurrent administration of biologic DMARDs or TNF-antagonists under Precautions).
