IV Individualised dose based on body wt, desired factor IX rise & reciprocal of observed recovery (0.77 dL/kg for patient ≥12 yr; 1 dL/kg for patient <12 yr). Max inj rate: 5 mL/min.
On-demand treatment: Minor or moderate haemarthrosis, muscle bleeding (except iliopsoas) or oral bleeding 30-60 IU/dL required factor IX level. Maintenance dose after 24-72 hr if there is further evidence of bleeding.
Life-threatening haemorrhages, deep muscle bleeding including iliopsoas 60-100 IU/dL required factor IX level. Repeat every 24-72 hr for 1st wk, then maintenance dose wkly until bleeding stops & healing is achieved.
Minor surgery including uncomplicated tooth extraction 50-80 IU/dL required factor IX level (pre- & post-op). If needed, maintenance dose can be provided after 24-72 hr until bleeding stops & healing is achieved.
Major surgery 60-100 IU/dL required factor IX level (pre- & post-op). Repeat every 24-72 hr for 1st wk, then maintenance dose 1-2 times wkly until bleeding stops & healing is achieved.
Long-term prophylaxis Patient w/ severe haemophilia B Usual dose: 35-50 IU/kg once wkly. Some patients who are well-controlled on a once-wkly regimen might be treated w/ up to 75 IU/kg on 10- or 14-day interval. After a bleeding episode during prophylaxis, maintain prophylaxis regimen as closely as possible, w/ 2 doses administered at least 24 hr apart, but longer if deemed suitable for the patient.
Ped patient 35-50 IU/kg once wkly.
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