High BP 150 mg once daily. May be increased to 300 mg once daily depending on BP response. High BP & type 2 DM w/ kidney disease 300 mg once daily. Dose may be lowered initially in patients on haemodialysis, or elderly >75 yr.
Dual blockade of renin-angiotensin-aldosterone system through combined use of ACE inhibitors, AIIAs or aliskiren is not recommended. Patients suffering from excessive vomiting or diarrhoea; heart problems; undergoing surgery or receiving anaesth. Perform regular blood tests, especially for measuring blood K levels in case of poor kidney function in patients w/ diabetic kidney disease. Check kidney function, BP, & amount of blood electrolytes (eg, K) at regular intervals. Lactose intolerance. Occasional dizziness or weariness may occur during treatment. Kidney problems. Pregnancy & lactation. Childn & adolescents.
Dizziness, feeling sick/vomiting, fatigue & raised levels of creatine kinase. High BP & type 2 DM w/ kidney disease: Increased level of K. Dizziness & low BP when getting up from a lying or sitting position, pain in joints or muscles, decreased Hb levels.
Drug Interactions
Higher frequency of adverse events (eg, hypotension, hyperkalaemia & decreased renal function including acute renal failure) in combined use w/ ACE inhibitors, AIIAs or aliskiren. Blood checks may be needed when taking K supplements; salt substitutes containing K; K-sparing medicines (eg, certain diuretics); medicines containing lithium. Reduced effect w/ NSAIDs.
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