Isoxsuprine: Indication, Dosage, Side Effect, Precaution

Generic Medicine Info Patient Medicine Information

This information is not country-specific. Please refer to the Hong Kong prescribing information.

Generic Medicine Info

Indications and Dosage

Intramuscular
Premature labour

Adult: Once premature labour is arrested through IV infusion, administer 10 mcg via IM inj 3-8 hourly. Max treatment duration: 48 hours. Dosage and treatment recommendations may vary among countries and individual products (refer to specific product guidelines).

Intravenous
Premature labour

Adult: Initially, 200-500 mcg/min via IV infusion using a syringe pump. Dose may be adjusted based on patient's response or until control is reached. Max treatment duration: 48 hours. Dosage and treatment recommendations may vary among countries and individual products (refer to specific product guidelines).

Oral
Cerebrovascular and peripheral vascular disease

Adult: 10-20 mg 3 or 4 times daily. Dosage and treatment recommendations may vary among countries and individual products (refer to specific product guidelines).

Administration

May be taken with or without food. May be taken w/ meals, milk or antacids to minimise GI discomfort.

Reconstitution

IV infusion: Dilute with an appropriate amount of infusion solution to prepare the recommended concentration. Instructions for reconstitution may vary among individual products and between countries (refer to specific product guidelines).

Contraindications

Recent arterial haemorrhage.

Special Precautions

Not intended to be given for premature labour if an infection is present. Should not be used immediately postpartum. Pregnancy and lactation.

Adverse Reactions

Significant: Maternal pulmonary oedema and fetal tachycardia (IV), severe rash.
Cardiac disorders: Tachycardia, chest pain.
Gastrointestinal disorders: Abdominal distress, nausea, vomiting.
Nervous system disorders: Dizziness.
Vascular disorders: Hypotension, flushing.

Pregnancy Category (US FDA)

IV/Parenteral/PO: C

Monitoring Parameters

Monitor blood pressure, hydration (maternal), and heart rate (maternal and fetal) during the IV infusion.

Drug Interactions

Concurrent administration with other vasodilators and anti-hypertensive agents (e.g. diazoxide) may cause severe hypotension.

Action

Description:
Mechanism of Action: Isoxsuprine is a vasodilator and β-adrenergic receptor stimulator. It directly relaxes the vascular and uterine smooth muscle. It increases muscle blood flow and decreases peripheral vascular resistance. Additionally, it may also produce positive chronotropic and inotropic effects on the heart and may increase cardiac output.
Pharmacokinetics:
Absorption: Well absorbed from the gastrointestinal tract. Time to peak plasma concentration: Approx 1 hour (oral).
Distribution: Crosses the placenta.
Excretion: Mainly via urine (as conjugates). Plasma elimination half-life: Approx 1.5 hours.

Chemical Structure

Storage

Store not exceeding 30°C.

MIMS Class

Drugs Acting on the Uterus / Peripheral Vasodilators & Cerebral Activators

ATC Classification

C04AA01 - isoxsuprine ; Belongs to the class of 2-amino-1-phenylethanol derivative agents. Used as peripheral vasodilators.

References

Buckingham R (ed). Isoxsuprine Hydrochloride. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 10/05/2024.

Duvadilan (Zuellig Pharma Corporation). MIMS Philippines. http://www.mims.com/philippines. Accessed 10/05/2024.

Duvaprine (Vamsler Phils, Inc). MIMS Philippines. http://www.mims.com/philippines. Accessed 10/05/2024.

Evaprine (MedEthix, Inc.). MIMS Philippines. http://www.mims.com/philippines. Accessed 10/05/2024.

Isoxilan (Biofemme, Inc.). MIMS Philippines. http://www.mims.com/philippines. Accessed 10/05/2024.

Isoxsuprine. Gold Standard Drug Database in ClinicalKey [online]. Elsevier Inc. https://www.clinicalkey.com. Accessed 10/05/2024.

Isoxsuprine. UpToDate Lexidrug, Lexi-Drugs Multinational Online. Waltham, MA. UpToDate, Inc. https://online.lexi.com. Accessed 10/05/2024.

Solvaprine 10 mg Tablet (Vamsler Phils. Incorporated). MIMS Philippines. http://www.mims.com/philippines. Accessed 11/06/2024.

Disclaimer: This information is independently developed by MIMS based on Isoxsuprine from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2024 MIMS. All rights reserved. Powered by MIMS.com