Itranstad Drug Interactions

Contraindicated concomitant administration: Terfenadine, Astemizole, Cisapride, Dofetilide, Pimozide and Quinidine.
Concomitant administration to be monitored: Enzyme-inducing drugs e.g., Rifampicin and Phenytoin, significantly reduce the oral bioavailability of Itraconazole. Consequently, monitoring of the Itraconazole plasma concentrations is advised when enzyme-inducing agents are co-administered.
In vitro studies have shown that there are no interactions on the plasma protein-binding between Itraconazole and Imipramine, Propranolol, Diazepam, Cimetidine, Indomethacin, Tolbutamide and Sulfamethazine and Warfarin.
Drug interactions have been reported when concomitant administration with Cyclosporine A and Itraconazole at dosage of 40 mg daily. So that, Cyclosporine A concentrations should be monitored at the initiation of Itraconazole therapy, if necessary, the dose of Cyclosporine A should be reduced.
With Digoxin and similar, the drug interactions have been established. But vomiting and nausea have been reported in patients concomitantly receiving Itraconazole.
No interaction of Itraconazole with AZT (Zidovudine) has been observed.
No inducing effects of Itraconazole on the metabolism of Ethyloestradiol and Norethisterone were observed.