Usual course of therapy: 7 days (may range from 5-10 days).
Adult & childn ≥40 kg Acute tonsillitis & pharyngitis, acute bacterial sinusitis; cystitis; pyelonephritis; uncomplicated skin & soft tissue infections 250 mg bd.
Acute otitis media; acute exacerbations of chronic bronchitis 500 mg bd.
Lyme disease 500 mg bd for 14 days (range of 10-21 days).
Childn <40 kg Acute tonsilitis & pharyngitis, acute bacterial sinusitis 10 mg/kg bd. Max: 125 mg bd.
Cystitis; uncomplicated skin & soft tissue infections 15 mg/kg bd. Max: 250 mg bd.
Pyelonephritis 15 mg/kg bd to max 250 mg bd for 10-14 days.
Lyme disease 15 mg/kg bd to max 250 mg bd for 14 days (10-21 days).
Childn ≥2 yr weighing <40 kg Otitis media w/ more severe infections 15 mg/kg bd to max 250 mg bd.
Patient w/ renal impairment, CrCl 10-29 mL/min/1.73 m2 Standard individual dose given every 24 hr,
<10 mL/min/1.73 m2 Standard individual dose given every 48 hr.
During haemodialysis Give a single additional standard individual dose at the end of each dialysis.
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