Myogenic adverse reactions including myasthenia & myositis especially in patients w/ risk factors eg, >65 yr, uncontrolled hypothyroidism, renal disease. Control hypercholesterolemia w/ appropriate diet, exercise & wt reduction in obese patients before instituting therapy. Non-serious & reversible-upon-discontinuation cognitive impairment (eg, memory loss, forgetfulness, amnesia, memory impairment, confusion). Increases in HbA1c & fasting serum glucose levels. Persistent elevations in serum transaminases. Perform liver function tests prior to & 12 wk after initiation of therapy & periodically thereafter. Caution in patients who consume substantial quantities of alcohol &/or have a history of liver disease. Uncomplicated myalgia. Promptly report unexplained muscle pain, tenderness or weakness, particularly if accompanied by malaise or fever. Discontinue if markedly elevated creatine phosphokinase levels occur or myopathy is diagnosed or suspected. Childn <10 yr.