Nexium耐信

Nexium

esomeprazole

Manufacturer:

AstraZeneca

Distributor:

Zuellig
/
Four Star
Concise Prescribing Info
Contents
Esomeprazole Mg
Indications/Uses
Dosage/Direction for Use
Tab Adult & adolescent ≥12 yr Treatment of erosive reflux esophagitis 40 mg once daily for 4 wk. An additional 4 wk for patients in whom esophagitis has not healed or have persistent symptoms. Long-term management w/ healed esophagitis to prevent relapse 20 mg once daily. Symptomatic treatment of GERD 20 mg once daily in patients w/o esophagitis. If symptom control has not been achieved after 4 wk, the patient should be further investigated. Adult In combination w/ an appropriate antibacterial therapeutic regimen for the eradication of H. pylori Healing of H. pylori associated duodenal ulcer or as prevention of relapse of peptic ulcers in patients w/ H. pylori associated ulcers: esomeprazole 20 mg w/ amoxicillin 1 g & clarithromycin 500 mg, all bd for 7 days. Patient requiring continued NSAID therapy Healing of gastric ulcers associated w/ NSAID therapy 20 mg once daily for 4-8 wk. Prevention of gastric & duodenal ulcers associated w/ NSAID therapy in patients at risk 20 mg once daily. Prolonged treatment after IV induced prevention of rebleeding of peptic ulcers 40 mg once daily for 4 wk after IV induced prevention of rebleeding of peptic ulcers. Treatment of Zollinger Ellison Syndrome 40 mg bd initially, 80-160 mg daily for maintenance, w/ doses >80 mg daily, doses should be divided & given bd. Granules (sachet) Treatment of endoscopically proven erosive reflux esophagitis Childn 1-11 yr w/ body wt of ≥10 kg to <20 kg 10 mg once daily for 8 wk. Childn 1-11 yr w/ body wt ≥20 kg 10 mg or 20 mg once daily for 8 wk. Symptomatic treatment of GERD 10 mg once daily for up to 8 wk.
Administration
May be taken with or without food: Tab: Swallow whole. For patients w/ swallowing difficulties, disperse tab in ½ glass of non-carbonated water. Do not use other liqd. Stir until tab dissolves into little pellets & drink immediately or w/in 30 min. Rinse glass w/ ½ glass of water & drink. Do not chew/crush tab/pellets. Mixt may be administered via a nasogastric tube. Granules: Add 1 sachet in 15-30 mL non-carbonated water. Stir until granules disperses & leave for a few min to thicken. Stir again & drink w/in 30 min. Do not chew/crush granules. Rinse w/ 15 mL water & drink. Mixt may be administered via a nasogastric tube.
Contraindications
Hypersensitivity to esomeprazole, substituted benzimidazoles or any other constituents of the formulation. Co-administration w/ nelfinavir.
Special Precautions
Exclude gastric malignancy before treatment. Patients on long-term & on-demand treatment. Patients w/ rare hereditary fructose intolerance, glucose-galactose malabsorption or sucrase-isomaltase insufficiency. Increased risk of gastrointestinal infections; co-administration w/ atazanavir; concomitant use w/ clopidogrel. Patients at risk of osteoporosis. Severe hypomagnesemia, especially for patients expected to be on prolonged treatment or take other medications that may cause hypomagnesemia. Severe renal & hepatic impairment. Pregnancy & lactation. Tab: Childn <12 yr. Granules: Childn <1 yr or <10 kg.
Adverse Reactions
Headache; abdominal pain, constipation, diarrhoea, flatulence, nausea/vomiting.
Drug Interactions
Decreased absorption of ketoconazole, itraconazole & erlotinib. Increased absorption of digoxin. Decreased serum levels of atazanavir & nelfinavir. Increased plasma conc of diazepam, citalopram, imipramine, clomipramine & phenytoin. Increased Cmax & AUC of cilostazol & cisapride. Elevated INR w/ warfarin & other coumarin derivatives. Increased exposure w/ clarithromycin. Decreased exposure to the active metabolite of clopidogrel. Decreased serum levels w/ CYP2C19 or CYP3A4 inducers (eg, rifampicin & St. John's wort).
MIMS Class
Antacids, Antireflux Agents & Antiulcerants
ATC Classification
A02BC05 - esomeprazole ; Belongs to the class of proton pump inhibitors. Used in the treatment of peptic ulcer and gastro-oesophageal reflux disease (GERD).
Presentation/Packing
Form
Nexium FC tab 20 mg
Packing/Price
14's
Form
Nexium FC tab 40 mg
Packing/Price
14's
Form
Nexium gastro-resistant granules for oral susp 10 mg
Packing/Price
28 × 1's
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